Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

HEMATOLOGY > HEMATOPOIESIS > Flashcards

HEMATOPOIESIS Flashcards

1
Q

Process of blood cell formation

A

Hematopoiesis or hemopoiesis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Classical marker of hematopoietic stem cells

A

CD34

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Hematopoiesis is considered to start around the _____ day of embryonic development

A

19th

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Suggests that each of the blood cell lineages is derived from its own unique stem cell

A

Polyphyletic theory

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Suggests that all blood cells are derived from a single progenitor stem cell called a pluripotential stem cell

A

Monophyletic theory

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Most widely accepted theory among experimental hematologists

A

Monophyletic theory

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Three phases of hematopoiesis:

A

Mesoblastic/megaloblastic
Hepatic
Intramedullary/medullary/myeloid

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Chief site of hematopoeisis in mesoblastic stage

A

Yolk sac

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Chief site of hematopoeisis in hepatic stage

A

Fetal liver (also spleen, thymus, and lymph nodes)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Chief site of hematopoeisis in intramedullary stage

A

Bone marrow

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

First blood cells: primitive erythroblasts are formed during the first__ to __ weeks of life

A

2 to 8

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

PE are important in early embryogenesis to produce_________ necessary for delivery of oxygen to the embryonic tissues

A

Hemogobin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Yolk sac hematopoiesis differs from hematopoiesis that occurs later in that it occurs__________________

A

Intravascularly

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Predominant hemoglobin during the hepatic phase

A

Hb F

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

First fully developed organ in the fetus

A

Thymus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Major site of T cell production

A

Thymus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Produce B cells

A

Kidneys and spleen

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Hematopoiesis starts in the bone marrow cavity before the ____ month of fetal development

A

5th

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

The _____________ becomes the chief site of hematopoiesis by the end of 24 weeks’ gestation

A

Bone marrow

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Not a normal hematopoietic organ in adults; production may indicate disorder

A

Liver

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Produces lymphocytes in adult hematopoiesis

A

Lymph nodes, spleen, thymus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Contains developing erythroid, myeloid, lymphoid, and megakaryocytic cells

A

Bone marrow

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Considered to be a primary lymphoid organ with functions equivalent to that of Bursa of Fabricius

A

Bone marrow

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

The bone marrow is estimated to be capable of generating around_______ RBCs, ________ Granulocytes, and ________ platelets per kilogram of body weight daily

A

2.5 billion; 1 billion; 1.5 billion

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Q

Process of replacing red marrow by yellow marrow during development

A

Retrogression

26
Q

Between __ to __ years of age, adipocytes become more abundant and start to occupy the spaces in the long bones previously dominted by active marrow

A

5 to 7

27
Q

Eventually results in restriction of the red marrow in the adult to the

A

RSVP

28
Q

Has the ability of reverting back to active marrow in cases of increased demand on the bone marrow

A

Yellow marrow

29
Q

Hematopoietically active marrow

A

Red marrow

30
Q

Hematopoietically inactive marrow composed primarily of fat cells

A

Yellow marrow

31
Q

Lymphoid development occurs in

A

Primary lymphoid organs

32
Q

Primary lymphoid organs:

A

Bone marrow
Thymus

33
Q

Where T and B lymphocytes are derived

A

Primary lymphoid organs

34
Q

Major secondary lymphoid organs

A

Spleen and lymph nodes

35
Q

Major functions of major secondary lymphoid organs

A

Trapping and concentration of foreign substances
Main sites of production of antibodies and the induction of antigen-specific T lymphocytes

36
Q

Largest of the secondary lymphoid organs

A

Spleen

37
Q

Major organ in the body in which antibodies are synthesized and from which they are released into the circulation

A

Spleen

38
Q

Small ovoid, bean-shaped structures found in different areas throughout the body

A

Lymph nodes

39
Q

Removal of spleen

A

Splenectomy

40
Q

Enlargement of the spleen

A

Splenomegaly

41
Q

Increased hemolytic activity of the spleen caused by splenomegaly

A

Hypersplenism

42
Q

Any disorder characterized by a localized/genaralized enlargemento lymph nodes/lymph vessels

A

Lymphadenopathy

43
Q

Solid tumor neoplasm of lymphoid tissues

A

Lymphoma

44
Q

Minor secondary lymphoid organs:

A

Tonsils
Appendix
Peyer’s patches
MALT

45
Q

Can maintain hematopoietic stem cells and progenitor cells to generate various blood cells as a response to infectious agents or in pathologic myelofibrosis of the bone marrow

A

Liver

46
Q

Bone marrow collection sites:

A

Posterior superior iliac crest
Anterior superior iliac crest
Sternum
Anterior medial surface of the tibia
Spinous process of the vertebrae, ribs, or other red marrow-containing bones

47
Q

Preferred sites for bone marrow aspiration in adults

A

Posterior and anterior superior iliac crest

48
Q

Preferred site for bone marrow aspiration in children <2 years

A

Anterior medial surface of the tibia

49
Q

Indications for bone marrow examination:

A

Neoplasia diagnosis and staging
Marrow failure; cytopenias
Metabolic disorders
Infections
Monitoring of treatment

50
Q

Normal marrow cells:

A

Developing hematopoietic cells
Macrophages
Mast cells
Osteoblasts
Osteoclasts

51
Q

Largest cell in normal marrow

A

Megakaryocytes

52
Q

Marrow differential must have at least ___ cells to be counted

A

500

53
Q

Proportion of myeloid cells to nucleated erythroid precursors in the bone marrow aspirate

A

M:E ratio

54
Q

Bone marrow smears should be retained for

A

10 years

55
Q

Disturbs bone marrow architecture

A

Bone marrow aspirate

56
Q

Spread as a smear on a slide, stained, and examined

A

Bone marrow aspirate

57
Q

Used for analysis of individual cell morphology

A

Bone marrow aspirate

58
Q

Bone marrow removed intact without disturbing the bone architecture

A

Bone marrow biopsy

59
Q

Used for analysis of bone marrow architecture

A

Bone marrow biopsy

60
Q

Blood cell production outside the bone marrow

A

Extramedullary hematopoiesis

61
Q

Extramedullary hematopoiesis occurs mainl in the

A

Liver and spleen

HEMATOLOGY (6 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions