Hematology Biochemistry

Question 1

Glutathione peroxidase

Answer 1

Glutathione peroxidase is the general name of an enzyme family with peroxidase activity whose main biological role is to protect the organism from oxidative damage

Question 2

Hemosiderin or haemosiderin

Answer 2

Hemosiderin or haemosiderin is an iron-storage complex. The breakdown of heme gives rise to biliverdin and iron. The body then traps the released iron and stores it as hemosiderin in tissues. Hemosiderin is also generated from the abnormal metabolic pathway of ferritin.

Hemosiderin is an insoluble protein-iron complex, containing approximately 37 % iron by weight. Iron in ferritin and hemosiderin is in the ferric form Fe+3

Question 3

Hepcidin

Answer 3

Hepcidin is a regulator of iron metabolism. Hepcidin inhibits iron transport by binding to the iron export channel ferroportin which is located on the basolateral surface of gut enterocytes and the plasma membrane of reticuloendothelial cells (macrophages).