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Hematology Flashcards

(88 cards)

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1
Q

4 Sites of hematopoiesis

A

Yolk sac, liver, spleen, bone marrow

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2
Q

2 heme precursors

A

Succinyl CoA

Glycine

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3
Q

Source of energy by the RBC

A

Anaerobic glycolysis

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4
Q

Vitamin B12 and folic acid deficiency

A

Megaloblastic anemia

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5
Q

Last stage of RBC with a nucleus

A

Orthochromatic erythroblast

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6
Q

Premature RBCs, increased in hemolysis

A

Reticulocyte

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7
Q

Hemoglobin with 2 alpha, 2 beta chains

A

Adult hemoglobin

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8
Q

Hemoglobin with 2 alpha, 2 gamma chains

A

Fetal hemoglobin

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9
Q

Transfers iron in the blood

A

Transferrin

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10
Q

Stores iron in the liver

A

Ferritin

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11
Q

For additional iron storage

A

Hemosiderin

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12
Q

Release histamine and heparin, involved in allergies

A

Basophils

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13
Q

Process that requires glycoprotein 1b and von willebrand factor

A

Platelet adhesion

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14
Q

Process that requires glycoprotein IIb-IIIa and fibrinogen

A

Platelet aggregation

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15
Q

Smallest Ig

A

IgG

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16
Q

Largest Ig

A

IgM

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17
Q

Ig involved in allergies and parasitic infections

A

IgD

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18
Q

Patches of dilated endoplasmic reticulum that appear as sky blue cytoplasmic puddles

A

Dohle bodies

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19
Q

Distinctive needle-like azurophilic granules found in myeloblasts

A

Auer rods

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20
Q

Small lymphocytes disrupted in the proces of making smears

A

Smudge cells

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21
Q

Large cells with multiple nuclei or a single nucleus with multiple lobes

A

Reed-sternberg cells

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22
Q

Cells found in adult T-cell lymphoma which appears to have multi-lobulated nuclei

A

Cloverleaf or flower cells

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23
Q

Deatructive plasma cell tumors involving axial skeletons

A

Plasmacytoma

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24
Q

Fiery red cytoplasm

A

Flame cells

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25
Pink globular cytosplasmic inclusions
Russel bodies
26
Blue globular cytoplasmic inclusions
Dutcher bodies
27
M proteins causing RBCs to stick in linear arrays
Rouleaux conformation
28
Erythroblasts with iron-laden mutichondria visible as perinuclear granules
Ringed sideroblast
29
Neutrophils with only 2 nuclear lobes
Pseudo-pelger huet cells
30
Megakaryocytes with single nuclear lobes or multiple separate nuclei
Pawn ball megakaryocytes
31
Premature release of nucleated erythroid and early granulocyte progenitors
Leukoerythroblastosis
32
Cells that were probably damaged during the birthing process in the fibrotic marrow
Teardrop cells or dacrocytes
33
Pentalaminar tubules, often with a dilated terminal end (tennis racket-like appearance)
Birbeck granules
34
Small yellow brown, brown or rust colored foci in the spleen
Gandy-gamma nodules
35
Dohle bodies
Severe infection
36
Auer rods
AML
37
Sea blue histiocytes
CML
38
Smudge cells
CLL
39
Reed sternberg cells
Hodgkin's lymphoma
40
Cloverleaf or flower cells
Adult T-cell lymphoma
41
Plasmacytoma
Multiple myeloma
42
Flame cells
Multiple myeloma
43
Russel bodies
Multiple myeloma
44
Dutcher bodies
Multiple myeloma
45
Rouleaux formation
Multiple myeloma
46
Ringed sideroblasts
Sideroblastic anemia
47
Pseudo-Pelger-Huet cells
Myelodysplastic syndrome
48
Pawn ball megakaryocytes
Myelodysplastic syndrome
49
Leukoerythroblastosis
Primary myelofibrosis
50
Teardrop cells or dacrocytes
Primary myelofibrosis
51
Birbeck granules
Langerhans cell histiocytosis
52
Gandy gamna nodules
Congestion of the spleen
53
HL vs NHL: associated with HIV and immunosuppression
NHL
54
HL vs NHL: multiple peripheral nodes; extranodal involvement common, non-contiguous spread
NHL
55
HL vs NHL: low grade fever, night sweats, weight loss
HL
56
HL vs NHL: EBV association, bimodal distribution
HL
57
Most common type of HL
Nodular sclerosis
58
Lacunar variant RS cells is a characteristic of what type of HL
Nodular sclerosis
59
HL with best prognosis
Lymphocyte rich Mononuclear varianf RS cells
60
Type of HL that contains popcorn cells
Lymphocyte predominant
61
HL with worst prognosis
Lymphocyte-depleted
62
Most common type of NHL
Diffuse large B cell
63
Translocation on chromosome 8; presents with starry-sky pattern
Burkitt's lymphoma
64
Biopsy reveals homogenous population of small lymphocytes; does not have centroblasts and proliferation centers
Mantle cell lymphoma
65
Excess light or heavy chains along with complete Ig synthesized by neoplastic plasma cells
Bence-Jones proteins
66
Tumor of thymus associated with myasthenia gravis and pure red cell aplasia
Thymoma
67
Most important monoclonal gammopathy usually presenting as tumorous masses scattered throughout the skeletal system
Multiple myeloma
68
Small hyperchromic RBC lacking central pallor
Spherocytes
69
Small dark nuclear remnants in RBCs of asplenic patients
Howell-jolly bodies
70
Membrane-bound precipitates on denatured globin chains
Heinz bodies
71
RBCs with damaged membranes due to removal of Heinz bodies by splenic macrophages
Bite cells
72
RBCs shaped like curved blades
Sickle cells
73
Dehydrated RBCs with bull's eye appearance
Target cells (codocytes)
74
Fragmented RBCs; also called helmet cells if cut in half
Schistocytes
75
RBCs with spikes
Burr cells or echinocytes
76
Spherocytosis
Hereditary spherocytosis
77
Howell jolly bodies
Asplenia
78
Heinz bodies
G6PD deficiency
79
Bite cells
G6PD deficiency
80
Target cells
Sickle cell anemia and thalassemia
81
Schistocytes
RBC trauma, drugs, HUS
82
Burr cells or echinocytes
RBC trauma
83
Triad of hemolytic anemia
Pallor Jaundice Splenomegaly
84
Differentiates intravascular from extravascular hemolysis
Presence of splenomegaly jn extravascular hemolysis
85
Autosomal dominant disorder caused by intrinsic defects in the red cell membrane; increased MCHC
Hereditary spherocytosis
86
Intracvascular hemolysis due to increased complement-mediated RBC lysis
Paroxysmal Nocturnal hemoglobinuria
87
Hemolytic anemia seen in DIC, TTP-HUS, SLE, and malignant hypertension
Micoangiopathic hemolytic anemia
88
Caused by trauma to RBCs in individuals with cadiac valve prostheses
Macroangipathic hemolytic anemia

Internal Medicine (8 decks)

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