Hematology Flashcards
MCV 80-100
Normocytic
MCV > 100
Macrocytic
Viruses that can cause aplastic anemia
Parvovirus B19, hepatitis virus, HIV, EBV
PBS finding in aplastic anemia
Hypocellularity and pancytopenia
Aplastic anemia with microcephaly, microphthalmia, hearing loss, limb anomalies
Fanconi’s anemia
Diamond-blackfan syndrome (congenital hypoplastic anemia)
Pure red cell aplasia
Iron def anemia most commonly affects what age group
6-24 months old
The most common hematologic disease of infancy and childhood
IDA
Defect in spectrin or ankyrin
Spherocytosis
Lack of enzyme needed by RBC to defend against oxidative stress
g6PD Deficiency
Crew cut or hair on end appearance on skull xray
Sickle cell anemia
Autoimmune platelet destruction
ITP
Due to acquired deficiency of metalloproteinase (ADAMTS13)
TTP
MCV
Microcytic
Most common childhood malignancy
ALL
The single most important prognostic factor in ALL
Treatment
Dx of ALL
BMA: > 25% of BM cells as a homogenous population of lymphoblasts
Remission
Poor prognostic factors for ALL
10 yrs Male WBC > 100 000 CNS leukemia Mediatinal mass
B symptoms
Lymphoma
- wt loss > 10 % over 3 mos
- unexplained high grade fever
- drenching night sweats
Reed sternberg cell
Hodgkin’s Lymphoma
Class of HD with best prognosis
Mixed cellularity
Most common solid tumors in childhood
Brain tumors
Most common posterior fossa tumor in childhood
Cerebellar astrocytoma
- also the best prognosis
