Hematology Flashcards

1
Q

MCV 80-100

A

Normocytic

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2
Q

MCV > 100

A

Macrocytic

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3
Q

Viruses that can cause aplastic anemia

A

Parvovirus B19, hepatitis virus, HIV, EBV

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4
Q

PBS finding in aplastic anemia

A

Hypocellularity and pancytopenia

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5
Q

Aplastic anemia with microcephaly, microphthalmia, hearing loss, limb anomalies

A

Fanconi’s anemia

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6
Q

Diamond-blackfan syndrome (congenital hypoplastic anemia)

A

Pure red cell aplasia

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7
Q

Iron def anemia most commonly affects what age group

A

6-24 months old

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8
Q

The most common hematologic disease of infancy and childhood

A

IDA

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9
Q

Defect in spectrin or ankyrin

A

Spherocytosis

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10
Q

Lack of enzyme needed by RBC to defend against oxidative stress

A

g6PD Deficiency

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11
Q

Crew cut or hair on end appearance on skull xray

A

Sickle cell anemia

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12
Q

Autoimmune platelet destruction

A

ITP

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13
Q

Due to acquired deficiency of metalloproteinase (ADAMTS13)

A

TTP

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14
Q

MCV

A

Microcytic

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15
Q

Most common childhood malignancy

A

ALL

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16
Q

The single most important prognostic factor in ALL

A

Treatment

17
Q

Dx of ALL

A

BMA: > 25% of BM cells as a homogenous population of lymphoblasts

18
Q

Remission

A
19
Q

Poor prognostic factors for ALL

A
10 yrs
Male 
WBC > 100 000
CNS leukemia
Mediatinal mass
20
Q

B symptoms

A

Lymphoma

  • wt loss > 10 % over 3 mos
  • unexplained high grade fever
  • drenching night sweats
21
Q

Reed sternberg cell

A

Hodgkin’s Lymphoma

22
Q

Class of HD with best prognosis

A

Mixed cellularity

23
Q

Most common solid tumors in childhood

A

Brain tumors

24
Q

Most common posterior fossa tumor in childhood

A

Cerebellar astrocytoma

- also the best prognosis

25
Q

2nd most common posterior fossa tumor of childhood

A

Medulloblastoma

- arises from the roof of 4th ventricle

26
Q

3rd most common posterior fossa tumor of childhood

A

Brain stem gliomas