hematology 3

Question 1

Begins at 5th to 7th week of gestation until 1 to 2 weeks after birth

Answer 1

Hepatic Period

Question 2

TRUE OR FALSE

Maturation is the term used to define the instance when two cells derived from the same precursor take
a separate route of development

Answer 2

FALSE (Commitment)

Question 3

1. Juxtacrine signaling- Neighbor cell will be stimulated by the cytokine produced by cell 1
2. Autocrine signaling- Produces own cytokine and stimulates own
3. Endocrine signaling- Cell 1 produces cytokine, and affects nearby cell
4. Paracrine signaling- Cytokine will go to bloodstream and meets target cell

A. 1 and 2 correct
B. 1,2,3 correct
C. 2 and 4 correct
D. All of the above

Answer 3

A- 1 and 2 correct

Question 4

What is symmetric and asymmetric cell division?

Answer 4

Symmetric - the hematopoietic stem cell will
give rise to the same stem cell

Asymmetric - the hematopoietic stem cell will
give rise to a different stem cell

Question 5

Difference between Extravascular hemolysis and Intravascular hemolysis

Answer 5

Extravascular hemolysis- Happens outside the blood vessel

Intravascular hemolysis- Happens within the blood vessels

Question 6

Identification

1. present in the first few hours after an ovum is
   fertilized; most versatile
2. found in adults and are limited to specific types
   of cells to form tissues
3. present several days after fertilization

Answer 6

1. Totipotential
2. Multipotential
3. Pluripotential

Question 7

Primary hematopoietic organ of the ff.

Mesoblastic phase
Hepatic phase
Myeloid phase

Answer 7

Mesoblastic phase- yolk sac

Hepatic phase- liver

Myeloid phase- bone marrow

Question 8

TRUE OR FALSE

Medullary - Blood production occurs in the bone marrow

Answer 8

TRUE

Question 9

Presence Of Nucleoli

Mature cells vs immature cells

Answer 9

Immature Cells- Presence of nucleoli

Mature Cells- Nucleoli not visible or absent

Question 10

Nuclear Shape

Mature cells vs immature cells

Answer 10

Immature Cells- Round or oval; except Monocytes

Mature Cells- WBCs: More segmented or lobed

Question 11

1. Deficiency of Acid sphingomyelinase

2. Deficiency of glucocerebrosidase

Answer 11

1. Niemann- Pick Disease

2. Gaucher Disease

Question 12

Is the amount of space occupied by the nucleus
in relationship to the space occupied by the
cytoplasm.

Answer 12

Nuclear: Cytoplasmic Ratio

Question 13

Also known as the vampire’s disease

Answer 13

Porphyria