Hematology Flashcards
the study of blood
hemotology
blood carries fuel to the cells. What is the fuel?
glucose
cells need _____ and ______
oxygen and glucose
how does blood transport oxygen?
hemoglobin attached to RBCs
what is the waste that cells remove?
CO2
what are the 4 components of blood?
plasma
RBC
WBC
Platelets
liquid part of blood (clear, yellow, protein rich)
plasma
biconcave disc (erythrocytes)
RBC
protect body from foreign bodies (immune function, leukocytes)
WBC
prevent hemorrhage and blood loss (thrombocytes)
platelets
what 3 basic functions does blood do?
1) prevent and eliminate infections
2) prevent loss of fluid (stops bleeding)
3) carries hormones
average amount of blood in human
5-6L
where are plasma proteins formed (clotting factors)
liver
where are blood cells formed
bone marrow
another name for IMMATURE BLOOD CELL
hemocytoblast
hemo = blood
cyto = cell
blast = immature
___ ___ mature into different types of blood cells (transform into what is needed)
stem cells
(body knows what needs to be replaced and replaces what is deficit)
life span of RBC
120 days
____ breaks down old RBCs and uses left over materials to make new RBCs
spleen
what is the purpose of RBCs
carry oxygen and remove carbon dioxide
what shape are RBCs
biconcave discs (maximizes surface area to carry more)
what is the term for low RBC count
anemia
what is the hormone secreted from kidneys to stimulate RBC production
erythropoietin
what is the term used for RBC production
erythropoiesis
where do RBCs get O2
lungs
what stimulates the kidneys to release erythropoietin
tissue hypoxia (lack of O2)
how many days does it take to restore RBC count
about 5 days
what is the oxygen carrying protein
hemoglobin
old RBCs get broken down via _____
hemolysis
what type of cell destroys RBCs in the spleen
phagocytes
what is saved after hemolysis
amino acids and iron (transferrin and ferritin)
transferrin = iron transport protein
ferritin = iron storing protein
normal size of cell
normocytic
smaller cell than normal
microcytic
larger cell than normal
macrocytic
normal cell color
normochromic
cell lacking in color (pale or lack hemoglobin)
hypochromic
name for WBCs
leukocytes (protect against foreign invaders)
higher WBC count >10
leukocytosis
leukocytosis could indicate _____
infection
normal WBC count
5,000-10,000 (5-10)
1% of total blood volume
low WBC count <5 (immune function is compromised)
leukopenia (e.g. chemo)
Leukocytes are released in response to _____
infection
true or false: Leukocytes move by blood, but can migrate into tissues (to fight)
true
three types of granulocytes
-eosinophils
-basophils
-neutrophils
three types of WBCs
-granulocytes
-monocytes
-lymphocytes
WBC listed from most to least in the blood
Never - neutrophils (60%)
Let - lymphocytes (30%)
Monkeys - monocytes (6%)
Eat - eosinophils (3%)
Bananas - basophils (1%)
WBC for allergic reactions
eosinophils
WBC involved in hypersensitivity stress reaction (viruses and fungal infections)
basophils
WBC released in response to bacteria, most prevalent, phagocytic
neutrophils
mature neutrophils
segs (segmental)
immature neutrophils
bands (increased in infection)
WBC largest in size, scavenger cells (clean the blood), destroys cancer cells
monocytes
WBC that is small, nondescript, and regulates immune response
lymphocytes
three types of lymphocytes
- B-cells
- T-cells
- Natural Killer Cells (NK)
memory cells, form antibodies (remember substance exposure for quicker response) allergies
B-cells
cell mediated (mediated immunity), kill foreign cells, kill tumor cells (HIV pts are deficient and at risk for cancer)
T-cells
surveillance cells, looking for foreign bodies
NK cells
WBC are released as an _____ _____
immune response (fight infection and foreign invaders)
part of the clotting mechanism
platelets
another name for platelets
thrombocytes
true or false: RBCs are fragments of cytoplasm w/o nuclei
false. RBCs do not have nuclei, but THROMBOCYTES do not either and are made from fragments of cytoplasm
excess platelet count
thrombocytosis (HR for blood clot)
insufficient platelet count
thrombocytopenia (HR for hemorrhage)
life span of platelets
10 days
hemostasis from bleeding is achieved in 5 stages. What are the 5 stages?
1) vessel spasm
2) formation of platelet plug
3) clot formation
4) clot retraction
5) clot dissolution
prevent ____ w/ a patient that has thrombocytopenia
injury
prevent ____ w/ a patient that has leukocytopenia
infection
what stops bleeding?
blood clot
blood vessels around injury constrict because of damage (reduce blood flow)
vessel spasm
stick to irregular edges on vessel (stick to form clot/plug)
formation of platelet plug
stabilize clot with FIBRIN
clot formation
after bleeding has stopped, hemostasis has occurred an in 30 min platelets begin to dissolve
clot retraction
fibrinolysis
clot dissolution
____ measures the size and volume of a single RBC
MCV (mean corpuscular volume)
80-95 fL
____ measures the average amount (mass) of Hgb within an RBC
MCH (mean corpuscular Hgb)
____ measures the average concentration (percentage) of Hgb within a single RBC
MCHC (mean corpuscular Hgb concentration)
How does the body compensate for anemia?
increase heart rate and resp rate