Hematologic / Oncologic

Question 1

Common organism in osteomyelitis in sickle cell patients

Answer 1

Salmonella

Question 2

Hemolysis after TMP-SMX (a sulfonamide medication)

Answer 2

Glucose-6-phosphate dehydrogenase deficiency

Question 3

Peripheral smear with schistocytes

Answer 3

Intravascular hemolysis
(due to mechanical destruction of RBC such as microangiopathic hemolytic anemia (MAHA), which can include TTP, HUS, or valvular hemolysis)

Question 4

Peripheral smear with spherocytes

Answer 4

Extravascular hemolysis (autoimmune hemolytic anemia) or hereditary spherocytosis

Question 5

Peripheral smear with Howell-Jolly bodies

Answer 5

Asplenia

Question 6

Peripheral smear with target cells

Answer 6

Thalassemia

Question 7

Whose platelets should be transfused into a baby with neonatal alloimmune thrombocytopenia?

Answer 7

Mother’s

Question 8

GI bleed at 2-7 days of life

Answer 8

Think classic vitamin K deficiency bleeding

Question 9

Patient with recent chemotherapy, fever, and acute abdomen

Answer 9

Think typhlitis (inflammation of cecum)

Question 10

Clotting factors in the common pathway

Answer 10

I, II, V, X
(think small dollar bills - $1, $2, $5, $10)

Question 11

• Neutropenia -> pancytopenia
• Pancreatic exocrine insufficiency
• Skeletal abnormalities

Diagnosis?

Answer 11

Schwachman-Diamond syndrome