Hematologic Emergencies Flashcards
A delicate balance of procoagulant and anticoagulant factors in blood is called __
Hemostasis
Bleeding controlled by the vasculature and platelets is called __
Primary Hemostasis
When plasma coagulation factors are needed to form a clot, this is called __
Secondary Hemostasis
The body’s first response to blood vessel injury is ___. It diverts blood glow from an injured area.
Vasoconstriction
There are 3 phases of primary hemostasis. These are __
Platelet adhesion, Platelet Activation, and Platelet aggregation
When plasma coagulation forms a stable hemostatic plug, this is called __
Secondary Hemostasis
Thrombocytopenia, Thrombopathia, and Von Willebrand’s Disease are disorders of __
Primary Hemostasis
Low platelet count (< 20,000 – 30,000/microliter) resulting in bleeding when inadequate platelets are available to form a plug is called __
Thrombocytopenia
This disease is characterized by immune-mediated destruction of either circulating platelets or, less commonly, marrow megakaryocytes. It can be acute, chronic, or recurrent
Immune-mediated thrombocytopenia
A platelet function defect in patients with a normal platelet count and history of surface bleeding is called __
Thrombopathia
Significant bleeding caused by thrombocytopenia and thrombopathia warrants a ___ transfusion. This is contraindicated in IMT.
Platelet
**This will not increase platelet numbers, but will allow clotting.
If a patient is acutely bleeding into a vital organ or uncontrollable, a __ transfusion is a better option
Whole Blood
This is the most common hereditary bleeding defect in dogs, caused by a deficiency in vWF (a large plasma protein). Common in Doberman Pinschers
von Willebrand’s Disease
There are three types of vWD - characterized by vWF concentration and multimer pattern:
Type 1 -
Type 2 -
Type 3 -
Type 1 – mild to mod dz with all multimer sizes reduced proportionally
Type 2 – mod to severe dz with lack of larger multimers
Type 3 – complete absence of vWFs
One type of therapy for von Willebrand’s Disease patients is a concentrate of vWF, FVIII, fibrinogen, and fibronectin that is derived from FFPt and has a lower risk of transfusion complications that FFP or whole blood. This is called __
Cryoprecipitate