hematologic alteratations Flashcards
Primary regulatory hormone for red cell
production
EPO
Organ responsible for red cell production
Erythron
8 μm in diameter, anucleate, discoid
in shape, and extremely pliable in order to traverse
the microcirculation successful
mature red cells
male anemic
<130g/L
female anemic
120g/L
10-15% blood loss (500-700ml)
hypotension and decreased organ perfusion
> 30%(1500ml)
postural hypotension*, tachycardia
hypovolemic shock including confusion, dyspnea, diaphoresis, hypotension, and tachycardia
> 40%
Palmar crease – full palm is very pale or is as pale
as its surrounding areas; when this occurs the Hgb is
already ____
<7g/dL or <70g/L
ACUTE HEMOLYSIS
o Acute back pain
o Free hemoglobin in the plasma and urine
o Renal failure
Hemoglobin<70-80 g/L
severe anemia
severe anemia tx
blood transfusion
If the cause of anemia is acute blood
loss, the red cell production rate
increases (positive feedback)
A reticulocyte response less than two to three
times normal indicates an
inadequate marriw response
reflects absolute or relative marrow failure
hypoproliferative
Ri >= 2.5
Hemolysis/ hemorrhage
Is defined as an increase in the hemoglobin above
normal. This increase may be real or only apparent
because of a decrease in plasma volume (spurious or
relative)
POLYCYTHEMIA
Petechiae pin point red rashes
Low counts of platelets
loss of 80> cc of blood per
cycle
menorrhagia
Normal platelet count:
150,000-350,000/μL
thrombocytopenia platelet count
<100,000/μL
a measurement of platelet
function, is abnormally increased if platelet
count is <100,000/μL; injury or surgery may
provoke excess bleeding
bleeding time
Thrombocytopenia- dengue
Increased destruction
Clopidogrel is avoided
I wk to 10 days
Aspirins are stopped
atleast 3 days to 1 week
major risk factor for arterial thrombosis
atherosclerosis
Pt (extrinsic )
1,2,5,7,10
Aptt (intrinsic)
11,9,8,19,5,2
is the most important part in identifying lymphadenopathies on a patient
palpation
Most frequent site of lymphadenopathy
neck
Supraclavicular lymph nodes
tb, sarcoidosis, toxoplasmosis
Tuberculosis
mesenteric lymphadenitis
comparably accurate (65– 90%) in the diagnosis of metastases to cervical lymph nodes
ct, mri
has been used to determine the long (L) axis, short (S) axis, and a ratio of long to short axis in cervical nodes.
ultrasonography
Fine-needle aspiration should be reserved for
thyroid nodules
Current procedure of choice for routine assessment
of spleen size
ultrasound
Spleen
LUQ
A common therapeutic indication for splenectomy is
TRAUMATIC OR IATROGENIC SPLENIC RUPTURE
occurs after immediate postsplenectomy
period, but within 2–3 weeks, blood cell
counts and survival of each cell lineage are
usually normal
leukocytosis (up to 25,000/μL) and
thrombocytosis (up to 1 × 106 /μL)