Hematologic Agents

Question 0

Hematopoeitic Growth Factor/s. Treatment of Megaloblastic anemia, vitamin b12 deficiency

Answer 0

Cyanocobalamin

Question 1

Hematopoeitic Growth Factor/s. Treatment of Iron Deficiency Anemia

Answer 1

FeSO4

Question 2

Hematopoeitic Growth Factor/s. Treatment of megaloblastic anemia, prevention of neural tube defects (spina bifida).

Answer 2

Folic acid

Question 3

Hematopoeitic Growth Factor/s. Anemia in chronic disease

Answer 3

Erythropoeitin

Question 4

Hematopoeitic Growth Factor/s. Treatment of neutropenia and agranulocytosis

Answer 4

Filgrastim

Question 5

Anticoagulant/s. Acute treatment of DVT, PE and AMI

Answer 5

Heparin

Question 6

Anticoagulant/s. Side effects of heparin

Answer 6

Bleeding, thrombocytopenia

Question 7

Anticoagulant/s. Monitor heparin treatment with?

Answer 7

PTT

Question 8

Anticoagulant/s. Low molecular weight heparin, less risk of thrombocytopenia, DOES NOT NEED monitoring

Answer 8

Enoxaparin

Question 9

Anticoagulant/s. Treatment of heparin induced thrombocytopenia

Answer 9

Lepirudin

Question 10

Anticoagulant/s. Antidote to heparin induced bleeding

Answer 10

Protamine sulfate

Question 11

Anticoagulant/s. Chronic anticoagulation

Answer 11

Warfarin

Question 12

Anticoagulant/s. Side effects of warfarin

Answer 12

Bleeding, skin necrosis, many drug interactions

Question 13

Anticoagulant/s. Antidote to warfarin (reversal over time)

Answer 13

Vitamin K

Question 14

What laboratory tests will you request to assess the extrinsic and intrinsic coagulation pathways?

Answer 14

PiTT
PTT for intrinsic pathway
PeT
PT for extrinsic pathway

Question 15

In patients requiring anticoagulation, why is an overlap between heparin and warfarin usually done?

Answer 15

Warfarin’s effect requires elimination of preformed clotting factors (8-60hours)

To bypass the initial prothrombic effect of warfarin (skin necrosis)