Autonomic Drugs

Question 0

Preferred substrate of beta receptors

Answer 0

Isoproterenol > epi > norepi

Question 1

Preferred substrates of alpha receptors

Answer 1

Epi > norepi

Question 2

Preferred substrate of delta receptors

Answer 2

Dopamine

Delta = dopamine

Question 3

Location of alpha 1 receptors

Answer 3

Smooth muscles

Question 4

Location of alpha 2 receptors

Answer 4

Nerve terminals

Question 5

Location of beta 1 receptors

Answer 5

Heart

“1 heart”

Question 6

Location of beta 2 receptors

Answer 6

Respi smooth muscles, uterus

“2 lungs”

Question 7

Location of delta 1 receptors

Answer 7

Splanchnic and renal vessels

Question 8

Location of delta 2 receptors

Answer 8

Nerve terminals of CNS

Question 9

Action of alpha 1 receptors

Answer 9

Vasoconstriction

Question 10

Action of alpha 2 receptors

Answer 10

Inhibits release of neurotransmitters

Question 11

Action of beta 1 receptors

Answer 11

Increase rate and contractility of heart

Question 12

Action of beta 2 receptors

Answer 12

Broncho/vasodilation

Question 13

Action of delta 1 receptors

Answer 13

Vasodilation of renal blood vessels

Question 14

Action of delta 2 receptors

Answer 14

Regulates neurotransmitters

Question 15

Cholinergic drug for bowel and bladder atony

Answer 15

Bethanechol

Question 16

Cholinergic drug for sjorgen syndrome

Answer 16

Pilocarpine

Question 17

Cholinergic drug for diagnosis of myasthenia gravis

Answer 17

Neostigmine

Question 18

Cholinergic drug for reversal of non Depolarizing neuromuscular block

Answer 18

Neostigmine

Question 19

Cholinergic drug for treatment of glaucoma

Answer 19

Physostigmine

Question 20

Cholinergic drug for diagnosis of bronchial hyperrreactivity

Answer 20

Methacoline

Question 21

Cholinergic drug for treatment of alzheimer’s disease

Answer 21

Donepezil

Question 22

What is myasthenia gravis

Answer 22

Autoimmune destruction of ACh receptors characterized by fluctuating proximal muscle weakness, ocular symptoms and bulbar symptoms

Question 23

Differnce between myasthenic crisis and cholinergic crisis

Answer 23

Myasthenic crisis is acute worsening of symptoms due to infection, stress or UNDER medication

Cholinergic crisis is activation of cholinoreceptors (skeletal muscle weakness and parasympathetic signs) due to OVER medication

Question 24

How does edrophonium dicferentiate myasthenic crisis from cholinergic crisis?

Answer 24

Edrophonium IMPROVES muscle strength in myasthenic crisis and WEAKENS muscle strength on cholinergic chrisis

Question 25

Small cell Ca may present with a myasthenia like paraneoplastic syndrome. What os this condition called

Answer 25

Lambert-Eaton Syndrome

Question 26

Signs and symptoms of organophasphate poisoning

Answer 26

"wet DUMBBELS" ``` Diarrhea Urination Miosis Bronchospasm Bradycardia Excitation (skeletal muscle and CNS) Lacrimation Sweating Salivation ```

Question 27

Cholinergic antagonist involved in induction of mydriasis and cycloplegia

Answer 27

Tropicamide

Question 28

Cholinergic antagonist. Sinus bradycardia

Answer 28

Atropine

Question 29

Cholinergic antagonist. Parkinsons disease

Answer 29

Benztropine

Question 30

Cholinergic antagonist. COPD

Answer 30

Ipratropium bromide

Question 31

Cholinergic antagonist. Motion sickness, sea sickness

Answer 31

Scopolamine

Question 32

Cholinergic antagonist. Gastrointestinal spasms

Answer 32

Hyoscine

Question 33

Cholinergic antagonist. Organophasphate poisoning, nerve gas poisoning

Answer 33

Atropine + Pralidoxime

Question 34

Muscarinic antagonists for Parkinson's disease

Answer 34

"try to park your benz, beep here" TRIhexyphenidyl BENZtropine BIPEriden

Question 35

Why is ipratropium the preferred bronchodilator in patients with comorbid COPD and heart disease?

Answer 35

Less likely to cause tachycardia and cardiac arrythmias

Question 36

Signs of atropine toxicity

Answer 36

``` "Alice in wonderland" HOT as a hare DRY as a bone RED as a beet BLIND as a bat MAD as a hatter ```

Question 37

Sympathomimetic. Anaphylaxis, adjunct to local anesthesia, cardiac arrest, croup

Answer 37

Epinephrine

Question 38

Sympathomimetic. Acute CHF, cardiac stress testing

Answer 38

Dobutamine

Question 39

Sympathomimetic. Acute CHF, shock (cardiogenic, septic)

Answer 39

Dopamine

Question 40

Sympathomimetic. Drug of last resort for shock

Answer 40

Norepinephrine

Question 41

Sympathomimetic. Nasal congestion, mydriasis WITHOUT cycloplegia

Answer 41

Phenylephrine

Question 42

Sympathomimetic. SE: Rebound hypertension on discontinuation

Answer 42

Clonidine

Question 43

Sympathomimetic. SE: hemolytic anemia (positive coombs)

Answer 43

Methylodopa

Question 44

Sympathomimetic. Bronchial asthma, COPD

Answer 44

Salbutamol

Question 45

Sympathomimetic. Tocolysis for preterm labor

Answer 45

Terbutaline

Question 46

Adrenergic antagonist. Preoperative treatment of pheochromocytoma

Answer 46

Phenoxybenzamine

Question 47

Adrenergic antagonist. Treatment of rebound hypertension

Answer 47

Phentolamine

Question 48

Adrenergic antagonist. Benign prostatic hyperplasia, FIRTS DOSE ORTHOSTATIC HYPOTENSION

Answer 48

Prazosin

Question 49

Adrenergic antagonist. Angina prophylaxis, hyperthyroidism, masks hypoglycemia in diabetes

Answer 49

Propanolol

Question 50

SE: Bronchospasm, Erectile dysfunction

Answer 50

Propanolol

Question 51

Adrenergic antagonist. Intrinsic Sympathomimetic Activity

Answer 51

"ISA-PinAce" Pindolol Acebutalol

Question 52

What drugs are used to control blood pressure in pheochromocytomas?

Answer 52

Phenoxybenzamine Phentolamine Labetalol

Question 53

Pharmacologic advantage of alpha 1 selectivity

Answer 53

Reflex tachycardia is less common and less severe

Question 54

Beta blocker with longest half life

Answer 54

Nadolol "Nasa DOLo"

Question 55

Bete blocker with shortest half life

Answer 55

Esmolol "Esmol (small)"