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Pharma Pearls (Topnotch) > Autonomic Drugs > Flashcards

Autonomic Drugs Flashcards

0
Q

Preferred substrate of beta receptors

A

Isoproterenol > epi > norepi

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1
Q

Preferred substrates of alpha receptors

A

Epi > norepi

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2
Q

Preferred substrate of delta receptors

A

Dopamine

Delta = dopamine

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3
Q

Location of alpha 1 receptors

A

Smooth muscles

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4
Q

Location of alpha 2 receptors

A

Nerve terminals

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5
Q

Location of beta 1 receptors

A

Heart

“1 heart”

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6
Q

Location of beta 2 receptors

A

Respi smooth muscles, uterus

“2 lungs”

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7
Q

Location of delta 1 receptors

A

Splanchnic and renal vessels

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8
Q

Location of delta 2 receptors

A

Nerve terminals of CNS

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9
Q

Action of alpha 1 receptors

A

Vasoconstriction

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10
Q

Action of alpha 2 receptors

A

Inhibits release of neurotransmitters

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11
Q

Action of beta 1 receptors

A

Increase rate and contractility of heart

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12
Q

Action of beta 2 receptors

A

Broncho/vasodilation

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13
Q

Action of delta 1 receptors

A

Vasodilation of renal blood vessels

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14
Q

Action of delta 2 receptors

A

Regulates neurotransmitters

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15
Q

Cholinergic drug for bowel and bladder atony

A

Bethanechol

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16
Q

Cholinergic drug for sjorgen syndrome

A

Pilocarpine

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17
Q

Cholinergic drug for diagnosis of myasthenia gravis

A

Neostigmine

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18
Q

Cholinergic drug for reversal of non Depolarizing neuromuscular block

A

Neostigmine

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19
Q

Cholinergic drug for treatment of glaucoma

A

Physostigmine

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20
Q

Cholinergic drug for diagnosis of bronchial hyperrreactivity

A

Methacoline

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21
Q

Cholinergic drug for treatment of alzheimer’s disease

A

Donepezil

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22
Q

What is myasthenia gravis

A

Autoimmune destruction of ACh receptors characterized by fluctuating proximal muscle weakness, ocular symptoms and bulbar symptoms

23
Q

Differnce between myasthenic crisis and cholinergic crisis

A

Myasthenic crisis is acute worsening of symptoms due to infection, stress or UNDER medication

Cholinergic crisis is activation of cholinoreceptors (skeletal muscle weakness and parasympathetic signs) due to OVER medication

24
Q

How does edrophonium dicferentiate myasthenic crisis from cholinergic crisis?

A

Edrophonium IMPROVES muscle strength in myasthenic crisis and WEAKENS muscle strength on cholinergic chrisis

25
Q

Small cell Ca may present with a myasthenia like paraneoplastic syndrome. What os this condition called

A

Lambert-Eaton Syndrome

26
Q

Signs and symptoms of organophasphate poisoning

A

“wet DUMBBELS”

Diarrhea
Urination
Miosis
Bronchospasm
Bradycardia
Excitation (skeletal muscle and CNS)
Lacrimation
Sweating
Salivation
27
Q

Cholinergic antagonist involved in induction of mydriasis and cycloplegia

A

Tropicamide

28
Q

Cholinergic antagonist. Sinus bradycardia

29
Q

Cholinergic antagonist. Parkinsons disease

A

Benztropine

30
Q

Cholinergic antagonist. COPD

A

Ipratropium bromide

31
Q

Cholinergic antagonist. Motion sickness, sea sickness

A

Scopolamine

32
Q

Cholinergic antagonist. Gastrointestinal spasms

33
Q

Cholinergic antagonist. Organophasphate poisoning, nerve gas poisoning

A

Atropine + Pralidoxime

34
Q

Muscarinic antagonists for Parkinson’s disease

A

“try to park your benz, beep here”
TRIhexyphenidyl
BENZtropine
BIPEriden

35
Q

Why is ipratropium the preferred bronchodilator in patients with comorbid COPD and heart disease?

A

Less likely to cause tachycardia and cardiac arrythmias

36
Q

Signs of atropine toxicity

A 
"Alice in wonderland"
HOT as a hare
DRY as a bone
RED as a beet
BLIND as a bat
MAD as a hatter
37
Q

Sympathomimetic. Anaphylaxis, adjunct to local anesthesia, cardiac arrest, croup

A

Epinephrine

38
Q

Sympathomimetic. Acute CHF, cardiac stress testing

A

Dobutamine

39
Q

Sympathomimetic. Acute CHF, shock (cardiogenic, septic)

40
Q

Sympathomimetic. Drug of last resort for shock

A

Norepinephrine

41
Q

Sympathomimetic. Nasal congestion, mydriasis WITHOUT cycloplegia

A

Phenylephrine

42
Q

Sympathomimetic. SE: Rebound hypertension on discontinuation

43
Q

Sympathomimetic. SE: hemolytic anemia (positive coombs)

A

Methylodopa

44
Q

Sympathomimetic. Bronchial asthma, COPD

A

Salbutamol

45
Q

Sympathomimetic. Tocolysis for preterm labor

A

Terbutaline

46
Q

Adrenergic antagonist. Preoperative treatment of pheochromocytoma

A

Phenoxybenzamine

47
Q

Adrenergic antagonist. Treatment of rebound hypertension

A

Phentolamine

48
Q

Adrenergic antagonist. Benign prostatic hyperplasia, FIRTS DOSE ORTHOSTATIC HYPOTENSION

49
Q

Adrenergic antagonist. Angina prophylaxis, hyperthyroidism, masks hypoglycemia in diabetes

A

Propanolol

50
Q

SE: Bronchospasm, Erectile dysfunction

A

Propanolol

51
Q

Adrenergic antagonist. Intrinsic Sympathomimetic Activity

A

“ISA-PinAce”

Pindolol
Acebutalol

52
Q

What drugs are used to control blood pressure in pheochromocytomas?

A

Phenoxybenzamine
Phentolamine
Labetalol

53
Q

Pharmacologic advantage of alpha 1 selectivity

A

Reflex tachycardia is less common and less severe

54
Q

Beta blocker with longest half life

A

Nadolol

“Nasa DOLo”

55
Q

Bete blocker with shortest half life

A

Esmolol

“Esmol (small)”

Pharma Pearls (Topnotch) (6 decks)

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