Hematologic

Question 1

Agranulocytosis

Answer 1

Causal agents: Dapsone, Clozapine, Carbamazepine,
Propylthiouracil, Methimazole, Colchicine,
Ganciclovir

Note: Drugs Can Cause Pretty Major Collapse of
Granulocytes

Question 2

Aplastic anemia

Answer 2

Causal agents: Carbamazepine, Methimazole, NSAIDs,
Benzene, Chloramphenicol, Propylthiouracil

Note: Can’t Make New Blood Cells Properly

Question 3

Direct Coombspositive
hemolytic
anemia

Answer 3

Causal agents: Penicillin, methylDopa, Cephalosporins

Note: P Diddy Coombs

Question 4

Drug reaction with
eosinophilia and
systemic symptoms
(DRESS)

Answer 4

Causal agents: Allopurinol, anticonvulsants, antibiotics, sulfa
drugs

Note: DRESS is a potentially fatal delayed hypersensitivity
reaction. Latency period (2–8 weeks)
followed by fever, morbilliform skin rash, and
frequent multiorgan involvement. Treatment:
withdrawal of offending drug, corticosteroids

Question 5

Gray baby syndrome

Answer 5

Causal agents: Chloramphenicol

Question 6

Hemolysis in G6PD

deficiency

Answer 6

Causal agents: Isoniazid, Sulfonamides, Dapsone, Primaquine,
Aspirin, Ibuprofen, Nitrofurantoin

Note: Hemolysis IS D PAIN

Question 7

Megaloblastic anemia

Answer 7

Causal agents: Hydroxyurea, Phenytoin, Methotrexate, Sulfa drugs

Note: You’re having a mega blast with PMS

Question 8

Thrombocytopenia

Answer 8

Causal agents: Heparin, Vancomycin, Linezolid

Note: Help! Very Low platelets

Question 9

Thrombotic

complications

Answer 9

Causal agents: Combined oral contraceptives, hormone
replacement therapy, SERMs (eg, tamoxifen,
raloxifene, clomiphene)

Note: Estrogen-mediated side effect