HEMA W3:3

Question 1

regulates the flow of particles entering and leaving the bone cavity

Answer 1

Endothelial cells

Question 2

secretes steroids that influences erythropoiesis and maintains bone integrity

Answer 2

Adipocytes

Question 3

phagocytic cells and secretes cytokines needed for the regulation

Answer 3

Macrophages

Question 4

bone forming cells; water-bug or comet appearance

Answer 4

Osteoblasts

Question 5

bone resorbing cells or destroying cells

Answer 5

Osteoclasts

Question 6

supports vascular sinuses and developing hematopoietic cells

Answer 6

Fibroblasts

Question 7

Confined in red bone marrow arranged by the extravascular cords; also known as the pluripotential
hematopoietic stem cells (PHSC) that is further differentiated to become myeloid and lymphoid lineages

Question 8

Located in the vascular sinuses supported by the trabeculae of a spongy bone

Question 9

contains surface receptors that is identified by immunophenotyping analysis

Answer 9

Stem cells

Question 10

develop in specific niches within the cords

Answer 10

Hematopoietic cells

Question 11

develop in small clusters adjacent to outer surface

Answer 11

Erythroblast

Question 12

located adjacent to the walls of vascular sinuses

Answer 12

Megakaryocytes

Question 13

located deep within the cords

Answer 13

Immature granulocytic cells

Question 14

Describes the origin of hematopoietic progenitor cells

Answer 14

STEM CELL THEORY AND KINETICS

Question 15

all blood cells are derived from single progenitor stem cells

Answer 15

Monophyletic theory:

Question 16

suggests that each blood cell is derived from its own unique stem cells

Answer 16

Polyphyletic theory

Question 17

Hematopoietic stem cell exists in the marrow in the ratio of ________ nucleated blood cells

Answer 17

1 per 1000

Question 18

determined to determine the percentage of cells undergoing mitosis in relation to the total number of cells being produced

Answer 18

Mitotic index

Question 19

Bone marrow can produce the following blood in a daily basis per kilogram body weight

Answer 19

o 2.5 billion erythrocytes
o 2.5 billion platelets
o 1 billion granulocytes

Question 20

Regulates the proliferation, differentiation, and maturation of hematopoietic precursor cells

Answer 20

CYTOKINES AND GROWTH FACTORS

Question 21

Responsible for stimulation OR inhibition of production, differentiation, and trafficking of mature blood cells and
their precursors

Answer 21

CYTOKINES AND GROWTH FACTORS

Question 22

Positive influence of cytokines and growth factors

Answer 22

KIT ligand, FLT3 ligand, GM-CSF, Interleukins (allows)

Answer 23

Interferons, Tumor necrosis factor (inhibits)