HEMA W2:1 Flashcards
Originated from Greek word “Haima” meaning blood and “Logos” meaning study.
HEMATOLOGY
discipline that studies the development of cells and diseases present in blood
Hematology
Described as worms in the blood
Athanasius Kircher 1657
Discovery of erythrocytes (RBC)
Swammerdam
1658
Human erythrocytes were described
Anton Van Leeuwenhoek 1674
Platelets were described as
petites plaques
Guilio Bizzozero 1842
Polymorphonuclear neutrophils is distinguished from other leukocytes
Wharton James 1846
First complete classification of leukocytes was established
Paul Ehrlich 1879
Development of Wright’s stain for cell staining
James Homer Wright 1902
Hematology was considered separate science from clinical pathology
1920
Automated analyzers are now able to differentiate and enumerate cells from one another
Present
➢ Wright’s stain technique remains as the foundation in blood cell identification through the practice of preparing a peripheral blood smear
➢ It has the capability to observe the morphology of the cells unlike the automated analyzers
Present
The blood is always in the
fluid state in VIVO (inside the body)
But coagulates withi
5-10 minutes in VITRO (outside)
almost in a neutral phase but changes
in the presence or the absence of a certain gas
Blood
Arterialblood
Bright red
Dark purplish red (sometimes even darker)
• Has a deoxygenated property because it
passes through the veins where waste
materials are locate
• Contains Carbon Dioxide rich red cells
(CO2)
Venous blood
Blood pH
7.35-7.45
If the blood is filled with oxygen →
More alkaline
Average pH
7.40
- Oxygenated blood (O2)
- Higher pH or normal
- Alkaline to Neutral pH
Arterial blood
Acidic State (Lower pH because CO2 is an acidic gas)
Venous blood
Specificgravityofbloodis
1.0555
Specificgravityofwateris
1.00
blood is _____x more viscous and thicker than water
o It’sbecausebloodcontainstheproteinsand
solutes
3.5-4.5
ml of blood contributes to the per kilogram of body weight
75-85mL
NORMAL BLOOD VOLUME
o Male adult
5-6L
NORMAL BLOOD VOLUME
o Female adult
4-5L
NORMAL BLOOD VOLUME
o Newborn:
150-350mL
NORMAL BLOOD VOLUME
o Average (Adult):
5 L