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Step2 > Hem/Onc > Flashcards

Hem/Onc Flashcards

1
Q

Deficiency of Gp1b

A

Bernard Soulier (large PLTs)

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2
Q

Deficiency of Giib/iiia

A

Glanzman thrombasthenia

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3
Q

Drugs that block Giib/iiia

A

tirofiban
eptifibatide
abciximab

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4
Q

Skin necorosis after warfain administration means?

A

Protein C or S deficiency

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5
Q

HIT tests?

A

PF4 antibody test

Serotonin release assay

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6
Q

MMA and homocysteine in folate and B12 deficiencies?

A

Homocysteine elevated in both

Folate = Normal MMA
B12 = Elevated MMA
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7
Q

Causes of B12 def?

A

IF deficiency
Pancreatic insufficiency
Crohn or any ileum disease
Diphyllobothrium latum

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8
Q

Waldenstrom vs. Multiple myeloma IGs?

A

Walden = IgM

MM = IgG, IgA

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9
Q

CD5+, smudge cells = ?

A

CLL

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10
Q

CLL treatment?

A

Fludarabine, chlorambucil

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11
Q

TRAP+ CLL treatment?

A

Cladribine

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12
Q

CRAB in Multiple Myeloma?

A

Calcium (up)
Renal (protein)
Anemia
Bone Lesions

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13
Q

M protein spike present in which diseases (5)?

A 
Amyloidosis
CLL
MGUS
Multiple Myleoma
Waldenstrom
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14
Q

MM treatment for elderly?

A

Melphan

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15
Q

AL
AA
B2 amyloidosis types?

A 
AL = light chains (MM, Waldenstrom)
AA = Acute phase (chronic inflammation/INFX)
B2 = Dialysis
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16
Q

Congo Red on stain?

A

Amyloidosis

17
Q

Warm AIHA causes?

A

IgG

SLE
CLL
Penicillins

18
Q

Cold AIHA causes?

A

IgM

M pneumoniae (Erythema multiforme)
EBV mono
19
Q

Fanconi Aneima vs. Diamond Blackfan Anemia?

A

Fanconi = Pancytopenia, no thumbs

DB = Macrocytic pure red cell aplasia

20
Q

Initial test in node with SCC to find source?

A

Panendoscopy

21
Q

TTP pentad?

A 
Fever
AIHA (Indirect bili, AST/ALT)
Thrombocytopenia
Renal failure
AMS
22
Q

TTP treatment?

A

Plasma Exchange (Replenishes ADAM13)

23
Q

Isoniazid causes what type of anemia? Cell size?

A

Microcytic Sideroblastic anemia

Alcohol, lead chloramphenicol

24
Q

Facial plethora + transient vision loss + elevated RBC/WBC/PLT?

Tx?

A

Polycythemia Vera

Phlebotomy

25
Q

First step for high likelihood DVT?

A

US before anticoagulation

26
Q

Soap bubble bone tumor?

A

Giant Cell

27
Q

Bone Mets in prostate CA tx?

A

RADIATION (Flutamide doesn’t work for mets, especially if patient has already had orchiectomy)

28
Q

PAS stain?

A

On lymphocytes (+ in Whipple disease)

29
Q

TdT stain?

A

Pre-B and Pre-T only (Immature)

30
Q

Elevated RDW in what conditions?

A

Nutritional/mineral deficiencies

Fe def

31
Q

Anemia

+ Specific nerve neuropathy + fatigue/memory loss?

A

Lead poisoning

32
Q

Vesicles on dorsum of hand, photosensitivity?

What associated disease?

A

PCT

HepC

33
Q

Indication for washed RBCs?

A

IgA def

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