Hem/Onc

Question 1

Deficiency of Gp1b

Answer 1

Bernard Soulier (large PLTs)

Question 2

Deficiency of Giib/iiia

Answer 2

Glanzman thrombasthenia

Question 3

Drugs that block Giib/iiia

Answer 3

tirofiban
eptifibatide
abciximab

Question 4

Skin necorosis after warfain administration means?

Answer 4

Protein C or S deficiency

Question 5

HIT tests?

Answer 5

PF4 antibody test

Serotonin release assay

Question 6

MMA and homocysteine in folate and B12 deficiencies?

Answer 6

Homocysteine elevated in both

Folate = Normal MMA
B12 = Elevated MMA

Question 7

Causes of B12 def?

Answer 7

IF deficiency
Pancreatic insufficiency
Crohn or any ileum disease
Diphyllobothrium latum

Question 8

Waldenstrom vs. Multiple myeloma IGs?

Answer 8

Walden = IgM

MM = IgG, IgA

Question 9

CD5+, smudge cells = ?

Answer 9

CLL

Question 10

CLL treatment?

Answer 10

Fludarabine, chlorambucil

Question 11

TRAP+ CLL treatment?

Answer 11

Cladribine

Question 12

CRAB in Multiple Myeloma?

Answer 12

Calcium (up)
Renal (protein)
Anemia
Bone Lesions

Question 13

M protein spike present in which diseases (5)?

Answer 13

Amyloidosis
CLL
MGUS
Multiple Myleoma
Waldenstrom

Question 14

MM treatment for elderly?

Answer 14

Melphan

Question 15

AL
AA
B2 amyloidosis types?

Answer 15

AL = light chains (MM, Waldenstrom)
AA = Acute phase (chronic inflammation/INFX)
B2 = Dialysis

Question 16

Congo Red on stain?

Answer 16

Amyloidosis

Question 17

Warm AIHA causes?

Answer 17

IgG

SLE
CLL
Penicillins

Question 18

Cold AIHA causes?

Answer 18

IgM

M pneumoniae (Erythema multiforme)
EBV mono

Question 19

Fanconi Aneima vs. Diamond Blackfan Anemia?

Answer 19

Fanconi = Pancytopenia, no thumbs

DB = Macrocytic pure red cell aplasia

Question 20

Initial test in node with SCC to find source?

Answer 20

Panendoscopy

Question 21

TTP pentad?

Answer 21

Fever
AIHA (Indirect bili, AST/ALT)
Thrombocytopenia
Renal failure
AMS

Question 22

TTP treatment?

Answer 22

Plasma Exchange (Replenishes ADAM13)

Question 23

Isoniazid causes what type of anemia? Cell size?

Answer 23

Microcytic Sideroblastic anemia

Alcohol, lead chloramphenicol

Question 24

Facial plethora + transient vision loss + elevated RBC/WBC/PLT?

Tx?

Answer 24

Polycythemia Vera

Phlebotomy

Question 25

First step for high likelihood DVT?

Answer 25

US before anticoagulation

Question 26

Soap bubble bone tumor?

Answer 26

Giant Cell

Question 27

Bone Mets in prostate CA tx?

Answer 27

RADIATION (Flutamide doesn’t work for mets, especially if patient has already had orchiectomy)

Question 28

PAS stain?

Answer 28

On lymphocytes (+ in Whipple disease)

Question 29

TdT stain?

Answer 29

Pre-B and Pre-T only (Immature)

Question 30

Elevated RDW in what conditions?

Answer 30

Nutritional/mineral deficiencies

Fe def

Question 31

Anemia

+ Specific nerve neuropathy + fatigue/memory loss?

Answer 31

Lead poisoning

Question 32

Vesicles on dorsum of hand, photosensitivity?

What associated disease?

Answer 32

PCT

HepC

Question 33

Indication for washed RBCs?

Answer 33

IgA def