Endo

Question 1

Hypothyroid metabolic anomalies?

Answer 1

HypoNatremia (Decreased H2O clearance)

Decreased LP Lipase (up TGs)

Decreased LDLR exression (Up LDL)

Question 2

PTU worst side effect?

Answer 2

Agranulocytosis

Fever+ Sore throat
Check CBC

Question 3

MEN1

Answer 3

Diamond

• Pituitary
• PTH
• Pancreas

(Gastrinoma Insulinoma, VIPoma)

Question 4

MEN2A

Answer 4

Square

• PTH
• Pheo
• Medullary Thyroid Ca

Question 5

MEN2B

Answer 5

Diamond

• Neuromas
• Pheo
• Medullary CA

Marfanoid

Question 6

Adrenal Insuff causes?

Answer 6

#1 worldwide = TB
#2 Autoimmune
CAH
N menigitidis
HIV
Histo
Hemorrhage

Question 7

Best initial test for cushings (high cortisol)?

Answer 7

24hr cortisol

2) overnight dexamethasone supp

NEXT: ACTH level

Question 8

Best initial test for adrenal insufficiency?

Answer 8

Cosynotrypsin (ACTH analog) test

Question 9

Flushing
R heat defect
Diarrhea?

Which nutrient gets deficient?

Answer 9

Cushing

Niacin (tryptophan)

Question 10

Graves vs. Exogenous on radiouptake iodine scan?

Answer 10

Graves (TSI) = Bright uptake

Exogenous = low uptake

Question 11

Weight loss assocaited with which anti-diabetic med?

What other s/e?

Answer 11

GLP1 agonists

Liraglutide
Exenatide

Question 12

Thiazolinedione contraindication?

Answer 12

Heart Failure (causes edema)

Question 13

SGLT2 inhibitors (-flozins) s/e?

Answer 13

UTI
Vulvovaginal candidiasis
Wt loss
LOTS OF URINATION

Question 14

TPO Ab with thyroid disease? Increased risk of which thyroid cancer?

Answer 14

Hashimotos

Lymphoma in thyroid

Question 15

Pituitary adenoma primary treatment?

Size difference for surg?

Answer 15

Cabergoline

> 3cm = surgery

Question 16

Adrenal insufficiency vs. Hypopituitary labs/PE?

Answer 16

AI = hypoaldo (HyperK, low Na)

Hypopituitary = normal aldo, low Thyroid symptoms + sexual impotence (low FSH/LH)

Question 17

Acute abdominal pain + hypocalemia?

Answer 17

Pancreatitis (Extracellular shift)

NOT IN CHRONIC PANCREATITIS

Question 18

Best treatment for diabetic nephropathy?

Answer 18

BP control (ACEI)

Question 19

Workup of acromegaly?

Answer 19

1. IGF1

2. Glucose TT – measure GH suppression

Question 20

Treatment for HHS?

Answer 20

SALINE (dont need as much tx as DKA)

Question 21

Endocrine causes of CK elevation (myopathy)?

Answer 21

HYPOthyroid
thyrotoxicosis
Cushing

Question 22

Worst S/E of untreated hyperythyroid?

Answer 22

Bone Loss

Question 23

Acute withdrawal of steroids, cortisol and aCTH levels?

Answer 23

BOTH LOW

Question 24

Sick thyroid syndrome vs. Subclinical hypothyroid?

Answer 24

Sick = Low T3 normal everything else

Subclinical = High TSH normal everything else

Question 25

Calcium relation to pH? (albumin)

Answer 25

Increased H = displaces Ca = Increased IONIZED Ca

alkalosis = decreased free Ca

Question 26

Diabetic Gastroparesis tx?

Answer 26

Smaller, frequent meals

METOCLOPRAMIDE

Question 27

Primary dysmenorrhea vs. Endometriosis/adenomyosis?

Answer 27

Primary = PAIN DURING MENSES

Endo/adeno = Pain BEFORE menses

Question 28

Tamoxifen S/e?

Answer 28

ENDOMETRIAL HYPERPLASIA
increased risk of endometrial CA
DVT/PE

GOOD FOR BONES

Question 29

Prevention of preterm labor?

Answer 29

Progestin (maintains cervical strength)

CCB/COXI work to slow already happening preterm

Question 30

Quad screen trisomy 18 vs 21?

Answer 30

18 = all down (underage)

21 = two up two down (21-2 -2 )

Question 31

Kleihauer -betke test?

Answer 31

Tests for Rho alloimmunization

determines does of Rhogam after delivery

Question 32

Subacute thyroiditis vs. silent thyroiditis?

Answer 32

Subacute (dequervian = painful)

Silent (Painless+ fever)

Both hyperthyroid with low radiouptake