Heart failure - Vasodilators

Question 1

T/F Vasodilators Effective in acute heart failure for they provide a reduction in preload (through venodilation) or reduction in afterload (through arteriolar dilation) or both

Answer 1

T

Question 2

T/F vasodilators are used in acute heart failure only

Answer 2

F: used in both acute and chronic heart failure

Question 3

T/F Long-term use of Hydralazine and Isosorbide dinitrate (ISDN) can reduce damaging remodeling of the heart

Answer 3

T

Question 4

synthetic form of the endogenous peptide brain natriuretic peptide (BNP) approved for use in acute (not chronic) cardiac failure

Answer 4

Nesiritide

Question 5

Nesiritide is use for both acute and chronic heart failure

Answer 5

F: for actue heart failure only

Question 6

Nesiritide is administerred orally

Answer 6

False: Short half-life of about 18 minutes and is administered as bolus IV dose followed by continuous infusion

Question 7

investigational synthetic analogs of these endogenous peptides and are in clinical trials

Answer 7

CARPERITIDE and ULARITIDE

Question 8

orally active competitive inhibitors of endothelin

Answer 8

BOSENTAN and TEZOSENTAN

Question 9

approved for use in pulmonary hypertension

Answer 9

Bosentan