Heart Failure - Phosphodiesterase Inhibitors

Question 1

T/F Phosphodiesterase inhibitors The family of enzymes that inactivate cAMP and cGMP

Answer 1

T

Question 2

T/F Most of their benefits appear to derive from vasoconstriction

Answer 2

FALSE: Have positive inotropic effects but most of their benefits appear to derive from vasodilation

Question 3

What is the MOA of bypyridines?

Answer 3

Increase myocardial contractility by increasing inward calcium flux in the heart during the action potential

Inhibition of phosphodiesterase cause an increase in cAMP and in contractility and vasodilation

Question 4

2 bypyridines that are the most successful

Answer 4

Inamorinone

Milrinone

Question 5

T/F Inamrinon and Milrinone are Active orally as well as parenterally and available on both

Answer 5

False: Active orally as well as parenterally but available only in parenteral forms.

-Both are now used only intravenously and only for acute heart failure or severe exacerbation of chronic heart failure

Question 6

Half-life of inamrinone and milrinone

Answer 6

3-6 hours

Question 7

Toxicity of inamrinone

Answer 7

nausea and vomiting, arrythmias, thrombocytopenia, and liver enzymes

Question 8

Toxicity of Milrinone

Answer 8

arrythmias