Heart failure

Question 1

Goals of drug therapy in heart Failure

Answer 1

improve symptome
revrse cardiac deterioration
prolong survival

Question 2

Drug classes helps heart failure

Answer 2

\+ve inotropes--Dobutamine,digoxin
ACE Inhibitors(prils)
Arbs (sartans)
Nitrates
B-Blockers
Diuretics

Question 3

Positive Inotropes

Answer 3

Digoxin

Dobutamine

Question 4

Digoxin obtained

Answer 4

From digitalis plant

it is a digitalis glycoside

Question 5

Function of digoxin

Answer 5

Digitalis blocks Na and K ATPase pump
increasing the flow of calcium ions into the cell
Ca ions are needed for the heart to pumpstrongly

Question 6

other functions of digoxin

Answer 6

negative chonotrope–decreased HR

negative dromotrope–decreased conduction velocity

Question 7

Digoxin bad part

Answer 7

EKG changes

Arrhythmias

Question 8

administration of digoxin

Answer 8

PO

IV

Question 9

Metabolism of digoxin

Answer 9

CYP450 3A4

Question 10

digoxin is contraindicated with

Answer 10

Dilitiazem and verapamil and quinidine

Question 11

Adverse drug reaction of digoxin

Answer 11

it is a narrow therapeutic index (NTI)
RXNs starts at GI(nausea and vomoting)
then moves to cardio( arrhythmias)
then moves to neuro(seizures and blurred vision and vision colour changes)

Question 12

2nd positive inotropes

Answer 12

Dobutamine