antiarrhythmic drugs

Question 1

a lidocaine analog drug that is resistant to first pass metabolism

Answer 1

Mexiletine

Question 2

Class 1B antiarrhthmic that has a major effect on the ischemic heart that healthy heart

Answer 2

Lidocaine

Question 3

Class 1 B anti ARR that is IV dosing only for anit ARR

Answer 3

Lidocaine

Question 4

ADR of Lidocaine

Answer 4

CNS effect( nervousness,paresthesia,tremor)

Question 5

Class 1 B Anti ARR that is PO dosing only for life thretening ventricular arr

Answer 5

mexiletine

Question 6

Drug interactions of lidocaine

Answer 6

Lidocaine +2D6 or 3A4 inhibitors increases toxicity

Question 7

MOA class 1 C anti ARR

Answer 7

Block open sodium channels

Dissociate very slowly

Slow conduction especially in the His-Purkinje system

Have the largest Phase 0 effect of all Class I drugs

Little effect on QT interval

Promote arrhythmias

Aren’t used that frequently any more

Question 8

CAST demonstrated that this drug causes increased mortality in patients post MI

Answer 8

Flecainide

Question 9

ADR of Flecainide

Answer 9

ventricular tachuarrhthmias
blood disorders(leukopenia and thrombocytopenia) and seizures

Question 10

this class 1C drug is givne to prevent supraventricular arr

Answer 10

Propafenone

Question 11

ADR of propafenone

Answer 11

QT prolongation,Ventricular tachyarrythmias,blood disorders

Question 12

Drug interactions of propafenone

Answer 12

increased toxicity when administered with 2D6 inhibitor

Question 13

This class of anti arrhyythmics are are to slow heart rate,decrease AV conduction velocity
increase Refractory period

Answer 13

Class 11 or beta blockers

Question 14

CLass 11 beta blockers are used to treat

Answer 14

Prevent and treat supraventricular arr
Prevent sudden deathin MI patients
Reduce ventricualr ectopic depolarization

Question 15

This drug is given in the IV form it is rapidly metabolized and have a 10 minute half life

Answer 15

esmolol

Question 16

these 2 drugs of class 2 ntiarr is given as IV or PO form

Answer 16

Metoprolol and propanolol

Question 17

This drug looks similar to throid hormone

Answer 17

amiodarone

Question 18

THis drug has unusual kinetics

Answer 18

Amiodarone

Question 19

THis drug has 40 day half life

Answer 19

Amiodarone

Question 20

ADR of amiodarone

Answer 20

bradycardia
QY prolongations and torsades de pointes
corneal microdeposits
photosensitivity
skin discoloration and sensitivity
thyroid disorders
hepatic disfunction
neuropathy
pulmonary fibrosis

Question 21

which class 3 Antiarr blocks sodium,Calcium and B-adrenoceptors

Answer 21

AMiodarone

Question 22

WHich class 3 AARR has IV dosing nad rapid onset in 5 minute

Answer 22

Ibutilide

Question 23

What is ibutilide used for

Answer 23

rapid cardioversion of afib and aflutter

Question 24

ADR of ibutilide

Answer 24

QT prolonation and torsades de pointes

Question 25

ADR of which drug shows Cinchonism which is a poisoning exhibited by conchona alkaloid?

Answer 25

Quinidine

Question 26

WHich class 1A drug has and ADR as diarrhea?

Answer 26

qUINIDINE

Question 27

WHich class 1 A drug shows ADR of excessive QT prolongation,TOrsades De Pointes andLupus like syndrome?

Answer 27

procainamaide

Question 28

Which class 1A drug has antimuscuranic effect along with excessive QT prolongtiona nd TOrsades De pointes?

Answer 28

Dysopyramide

Question 29

What class !A drug is given orally to prevent life threatening ventricular arrhythmias?

Answer 29

dysopyramide