Heart Embryology Flashcards

1
Q

What layer do the blood islands form in

A

Splanchnic Mesoderm

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2
Q

How does the primitive heart tube form?

A

When the blood islands fuse in the midline

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3
Q

Name the 6 sections of the Primitive heart tube from inlet to outlet

A

Sinus Venosus, Atrium, Ventricle, Bulbus Cordis, Truncus arteriosus, Aortic roots

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4
Q

Where does the RA form from (which sections)

A

Majority from the primitive atria, some from the sinus venosus

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5
Q

Where does the LA form from?

A

Some from the primitive atria, mostly from the proximal part of the pulmonary veins

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6
Q

Is the left atria smooth walled or rough walled? Explain why

A

Smooth. Forms from the proximal part of the pulmonary veins which are smooth walled

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7
Q

State the main differences between the fetal circulation and mature circulation

A

Fetal- Oxygenation and removal od CO2 in the placenta

Shunts are required to maintain fetal life

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8
Q

What path does the blood take in the fetus, starting at the placenta

A

Placenta–>Umbilical veins–> Bypasses liver in the ductus venosus–>leads into IVC–>Right atria–>Left atria through the foramen ovale–>Left ventricle–>Aorta
Note from the head and upper limbs blood goes into the SVC–>Right ventricle–>Pulmonary trunk–> Trunus Arteriosus–> aorta
Blood taken back to the placenta for oxygenation by the umbilical artery

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9
Q

Why does the right ventricle need to be used

A

For development, prevent atrophy

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10
Q

Name the three main shunts and say what they do

A

Ductus Venosus- By passes the liver
Foramen Ovale- Takes blood from the right atria to the left atria
Ductus Arteriosus- From the pulmonary trunk to the aorta

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11
Q

How many arches are there in the early arterial system

A

6

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12
Q

What do the fourth and Sixth arches become?

A

Fourth- To the right, the proximal part of the right subclavian artery
To the left, the arch of the aorta
Sixth- To the right the right pulmonary artery
To the left, thee left pulmonary artery and ductus arteriosus

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13
Q

What is PDA

A

Persistent communication between the aorta and the pulmonary artery
Ie the ductus arteriosus doesn’t shut

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14
Q

How does the foramen ovale form

A

1, Endocardial cushion forms (Separates the left and right orifices)

  1. Primum Septum forms from the roof of atria
  2. Gap at bottom
  3. hole opens up called the ostium primum
  4. Secundum Septum forms
  5. Ostium Secundum forms lower than the ostium primum
  6. Gap between the two walls allows blood to pass through
  7. When child born, pressure in the left atria increases, so higher than in the right
  8. Pushes walls together, walls fus so holes shut.
  9. Blood can no longer pass through. Leaves can indentation called the fossa ovali
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15
Q

Causes of Atrial Septum Defect

A

Septum Primum too short or resorbed, Septum Secundum too small

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16
Q

What is hypoplastic left heart syndrome. Possible causes?

A

Underdevelopment of the left side of the heart. Reduced blood flow to the left side, so atrophy

17
Q

How do the left and right ventricles get separated?

A

Superior and inferior cushions form in the atrioventricular canal.
A muscular portion of the wall grows upwards to the endocardial cushion
Last bit filled in by a membranous bit from the endocardial cushion

18
Q

How do the great arteries form?

A

Endocardial cushions appear in the truncus arteriosus. Grow upwards. Form a spiral septum. Separate the truncus arteriosus into the aorta and the pulmonary trunk

19
Q

What is the transpositon of the great arteries. Consequences?

A

When the aorta comes off the right ventricle, and the pulmonary trunk comes off the left ventricle
Means deoxygenated blood travels in the aorta–> Cyanosis

20
Q

What are the four things wrong with the heart in the tetralogy of Fallot

A

Overriding aorta- The aorta straddles the two ventricles
Large Ventricular septal defect- Hole between the left and right ventricles
Pulmonary stenosis (Narrowing of pulmonary trunk)
Leads to Right ventricular hypertrophy and needs to pump harder to output the same vol of blood