HC13 - Stem cells Flashcards
1
Q
stem cells (3)
A
- unspecialized cells that are able to proliferate over a longer period of time
- pluripotent
- essential for formation, maintenance and repair of tissues
2
Q
cell division of stem cells
A
self-renewal
3
Q
zygote
A
totipotent
4
Q
blastocyst > embryonic stem cells (ECS)
A
pluripotent
5
Q
germ layers > somatic stem cells in tissues
A
multipotent
6
Q
asymmetrical divison of stem cells
A
- environmental asymmetry
- divisional asymmetry > marker to remain a stem cell already present
7
Q
natural stem cells (4)
A
- embryonic
- neonatal
- adult/somatic
- cancer stem cells
8
Q
artificial stem cells
A
induced pluripotent stem cells
9
Q
ECS differentiation in culture occurs because of
A
environmental factors
10
Q
limitations in development hECS-based therapies (4)
A
- ethical objections
- xeno-free system
- presence of undifferentiated hECSs
- graft immune rejection
11
Q
adult hematopoietic stem cells for
A
bone marrow transplant > 1956: identical twins
12
Q
peripheral blood stem cells (2)
A
- G-CSF or GM-CSF mobilized from bone marrow
- apharesis
13
Q
neonatal hematopoietic stem cells in
A
umbilical cord blood
14
Q
brain
A
neural stem cells
15
Q
teeth
A
dental pulp stem cells
