HC11- Clinical radiotherapy Flashcards

1
Q

treatment cancer

A

surgery - radiotherapy - chemotherapy - immunotherapy

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2
Q

clinical factors radiotherapy (6)

A
  • tumor size
  • localization
  • primary tumor
  • metastases
  • histology
  • fitness patient
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3
Q

radiosensitivity > very sensitive

A

lymphoma, seminoma, small cell lung cancer

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4
Q

dosage very sensitive > microscopic

A

20-40 Gy

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5
Q

dosage very sensitive > macroscopic

A

30-60 Gy

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6
Q

radiosensitivity > average sensitivity

A

carcinoma

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7
Q

dosage average sensitivity > microscopic

A

40-60 Gy

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8
Q

dosage average sensitivity > macroscopic

A

60-80 Gy

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9
Q

radiosensitivity > not sensitive

A

sarcoma, glioblastoma, melanoma

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10
Q

dosage not sensitive > microscopic

A

60-80 Gy

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11
Q

dosage not sensitive > macroscopic

A

> 80 Gy

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12
Q

tissue sensitivity
- bone marrow
- hair
- brain
- lungs
- spinal cord
- kidneys
- small intestine
- skin

A
  • bone marrow = 8 Gy
  • hair = 10 Gy
  • brain = 30-60 Gy
  • lungs = 20-40 Gy
  • spinal cord = 50-60 Gy
  • kidneys = 15-20 Gy
  • small intestine = 40-70 Gy
  • skin = 70-80 Gy
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13
Q

challenge radiotherapy

A

killing the tumor without killing the patient

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14
Q

treatment recurring mammacarcinoma

A

hyperthermia and reirradiation

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15
Q

hyperthermia > WIRA

A

water-filtered infrared A > 434 MHz probe

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16
Q

advantages hyperthermia

A

allows for significant reductions in re-RT dose

17
Q

bladder cancer not invading muscle

A
  • 70% of cases
  • Ta-T1-cis, high
18
Q

bladder cancer invading muscle

A
  • 30% of cases
  • T2-T4
  • survival =24 months
19
Q

treatment bladder cancer (2)

A
  • External Beam Radiation Therapy (EBRT)
  • Barchytherapy
20
Q

PSA

A

Prostate Specific Antigen

21
Q

Gleason score (1-5 tumor differentiation)

A

first = most dominant differentiation, second = second most dominant differentiation

22
Q

treatment options (3)

A
  • active surveillance
  • curative
  • pallative
23
Q

curative treatment (2)

A
  • surgery
  • radiotherapy > + hormone therapy
24
Q

pallative treatment (3)

A
  • hormone therapy
  • chemotherapy
  • radiotherapy
25
Q

Brachytherapy I-125

A
  • for local tumors, low stage
  • advantage > high dose locally = 144 Gy, low dose in healthy tissue, one time
  • disadvantage > permanent, operation