Hardy Exam 1

Question 1

Describe internal (ER) formation of collagen synthesis.

Answer 1

Starts in ER > pre-collagen chain enters ER > Vit C needed to add OH groups to lysine and proline > glycosylation occurs > 3 procollagen chains form triple helix

Question 2

Describe the outer formation of collagen.

Answer 2

Procollagen secreted from ER to golgi and transported to ECM > procollagen peptidases com into ECM to cut N and C ends off > form into fibrils > Lysyl oxidase helps

Question 3

What is lysyl oxidase?

Answer 3

Enzyme that helps with the formation of covalent cross-linking to strengthen the collagen