Hallucinogens Flashcards
Psychedelic
mind manifesting, mind expanding
Psychoplastogen:
small molecules that produce rapid and sustained structural and functional neural plasticity
Examples of Psychoplastogen
Ketamine, MDMA, Scopolamine, LSD, psilocin
MDMA
In conjunction with psychotherapy for PTSD, Anxiety and Eating Disorders
Psilocybin
For treatment of a variety of disorders including Anxiety and Depression
LSD
Cluster headaches and Anxiety
Ibogaine
Addiction
Fungi
Claviceps purpurea
Ergotism Symptoms
Symptoms are gangrene, nervous spasms, psychotic delusions, convulsions
Assyrian cuneiform tablet
Mentions “noxious pustule in the ear of grain”
But symptoms are not associated specifically with the ergot fungus until 1676
Ignis sacer
Holy Fire
Burning sensation in extremities
Symptoms are retribution for sins
Modern Uses of Ergoline
Uterine contractions
Cause spontaneous birth
Used by European midwives to help increase contractions during difficult births
Other
Treat migraine
Reduce prolactin levels resulting from pituitary tumors
Reduce postpartum hemorrhage
Treat senility and Alzheimer’s dementia
Mechanism information and usefulness of these compounds is limited
Claviceps purpurea
Ergot alkaloids
Psilocybe mexicana
Psilocybin
Turbina corymbosa
Lysergic acid
Richard Evans Schultes
First botanist to record rituals and beliefs surrounding this sacred mushroom
Timothy Leary (Harvard professor)
1960’s investigated effects of eating magic mushrooms
Indole hallucinogens
Lysergic acid
Psilocybin
Catechol hallucinogens
Mescaline
Myristicin
Peyote cactus
Lophophora williamsii
Nutmeg
Myristica fragrans
Fly agaric mushroom
Amanita muscaria
Glutamate
endogenous excitatory neurotransmitter
Muscimol
Thought to be the most active compound in Fly agaric
Produces state of confusion, disorientation, sensory disturbances