Haemostasis

Question 1

1. Haemostasis is the ______ of bleeding and the maintenance of _______ _________.
2. There are four components to normal haemostasis: primary haemostasis is the formation of a _________ plug. Secondary haemostasis is the formation of a ______ clot. Thirdly is __________ then _______ defences.

Answer 1

1. Arrest, Vascular patency

2. Platelet, fibrin, fibrinolysis, anti-coagulant.

Question 2

1. Platelets are formed by _________ from ___________ cells in the bone marrow.
2. Name the protein factor to which platelets bind to create a plug in a vessel wall.

Answer 2

1. Budding, Megakaryocyte

2. Von Willebrand Factor

Question 3

1. Prothrombin is converted to ______ in association with Factors ___ and ____. Thrombin converts __________ to _____ allowing a clot to form.
2. In fibrinolysis plasminogen is converted to _____ by Tissue _________ Activator. ________ converts ______ to Fibrin ________ Products (FDP)

Answer 3

1. Thrombin, X and V, Fibrinogen to fibrin.

2. Plasmin, plasminogen, plasmin, fibrin, Degradation

Question 4

1. Identify some naturally occuring anticoagulants

2. Define thrombophilia

Answer 4

1. Serine Protease Inhibitors, Protein C and Protein S,

2. Deficiency in naturally occuring anticoagulants.