Haemolysis

Question 1

1. Define Haemolysis
2. Define Compensated Haemolysis
3. Define Decompensated Haemolysis

Answer 1

1. Haemolysis is premature red cell destruction
2. Increased red cell destruction compensated by increased red cell production.
3. Increased rate of red cell destruction exceeding bone marrow capacity for red cell production.

Question 2

1. Haemolysis results in _________ hyperplasia and an increase in red cell breakdown products such as ________.
2. The blood film shall be polychromatic because of __________.

Answer 2

1. Erythroid, Bilirubin

2. Reticulocytosis

Question 3

1. Haemolysis is classified as either ___________ or ____________. _________ when red cells are taken up by the spleen and liver. __________ when the red cells are destroyed within the circulation.

Answer 3

1. Extravascular, intravascular, extravascular, intravascular.

Question 4

1. __________ anaemia presents with splenomegaly and/or hepatomegaly. It also results in unconjugated ______________ and urobilinogenuria.
2. ___________ anaemia presents with ____________ (free Hb in blood), methaemalbuminaemia and _____________ where the urine appears pink. Also haemosiderinuria

Answer 4

1. Extravascular. bilirubinaemia,

2. intravascular, haemoglobinaemia, haemoglobinuria.