Haemopoeisis Flashcards
For how long do RBCs circulate the body?
120 days
What is the shape of the RBC?
It’s biconcave
No nucleus and no organelles
CHECK THE HISTOLOGY OF WHITE BLOOD CELLS
Yup
What is special about neutrophils?
They are in the first line of defence in case of a pathogen.
Why can neutrophils in lungs be harmful?
Neutrophils make elastase which break down elastin. This is not good in the lungs as recoil with be harder. This can lead to emphysema.
How do eosinophils stain?
In a reddish way since Eosin is what stains it most.
How do basophils stain?
In a purple way because haemotoxylin stains it most.
How do neutrophils stain?
In an intermediate between eosinophils and basophils. Pinkish.
What is the function of B cells?
Produce antibodies
What are the functions of T cells?
Recognise foreign proteins and activate other cells
Directly kill
Inhibit the immune response
What is the function of platelets?
To look for small breaks in blood vessels and serve as a primary plug. They signal to clotting factors to make a definitive clot.
What are the main cells in haemopoeisis?
Thrombocytes Erythtrocytes Mast cells Basophils Neutrophils Eosinophils Monocytes Natural killer cells T lymphocytes B lymphocytes
What is the precursor to Thrombocytes?
Megakaryocytes and common myeloid progenitors.
What is the growth factor that allows megakaryocytes to differentiate into thrombocytes?
Thrombopoeitin
What is the precursor to erythrocytes?
Common myeloid progenitor
What is the growth factor for common myeloid progenitor cells to turn into erythrocytes?
Erythropoeitin
What is the precursor to basophils, eosinophils, neutrophils and monocytes?
Myeloblasts
What is the growth factor for myeloblasts to turn into basophils, eosinophils, neutrophils and monocytes?
G-CSF
What is the precursor to Natural killer cells and T lymphocytes and B lymphocytes?
Common lymphoid progenitor
What is the growth factor for common lymphoid progenitor cells to turn into natural killer cells and T lymphocytes and B lymphocytes?
Interleukins
