Haemolytic Anaemias 1 Flashcards

1
Q

Definition

A

Breakdown of RBCs before their normal lifespan of 120 days

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2
Q

Increased unconjugated billirubin

A

All

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3
Q

Increased Urobilinogen

A

All

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4
Q

Increased LDH

A

All

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5
Q

Reticulocytosis

A

All

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6
Q

Pigmented gallstones

A

All

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7
Q

Increased free plasma Hb

A

Intravascular

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8
Q

Reduced haptoglobin

A

Intravascular

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9
Q

Haemoglobinuria (dark red urine)

A

Intravascular

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10
Q

Methaemalbuminaemia (Haem+Albumin in blood)

A

Intravascular

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11
Q

Splenomegaly

A

Extravascular

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12
Q

Hereditary Spherocytosis

A

Membrane Defect

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13
Q

Hereditary Ellptocytosis

A

Membrane Defect

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14
Q

G6PD Deficiency

A

Enzyme Defect

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15
Q

Pyruvate Kinase Deficiency

A

Enzyme Defect

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16
Q

Sickle Cell Disease

A

Haemoglobinopathies

17
Q

Thalassaemias

A

Haemoglobinopathies

18
Q

Immune

A

Autoimmune - Hot/Cold

Alloimmune - Haemolytic Transfusion Reaction

19
Q

Non-Immune

A

Mechanical e.g. Metal Valves, Trauma
PNH, MAHA
Infections
Drugs