Blood Tranfusions

Question 1

Destruction of fetal red cells due to high levels of maternal antibody

Answer 1

Haemolytic disease of the newborn

Question 2

Which Ig can cross the palcenta

Answer 2

IgG

Question 3

Most common Ab responsible and precaution taken

Answer 3

anti-D

Always transfuse RhD -ve blood to RdD -ve women of child bearing age

Question 4

Other Ab that can cause HDN

Answer 4

anti-c, anti-K, IgG ABO

Question 5

Prevention of antiD formation?

Answer 5

IM Anti_D Ig at high risk of feto-maternal haemorrhage
28 and 34 weeks routine prophylaxis
During pregnancy if sensitising event occurs
Delivery if baby is RhD +ve

Question 6

4 types of immediate immune response to transfusions

Answer 6

Wrong Blood ABO
Rebrile non-haemolytic
Allergic/ anaphylaxis
Transfusion related acute lung injury

Question 7

3 types of delayed immune response to transfusions

Answer 7

Delayed haemolytic transfusion reaction
Post-transfusion purpura
Transplant-associated GVHD

Question 8

2 Types of IMmediate non-immune reaction

Answer 8

Bacterial infection

Transfusion associated cardiac overload

Question 9

2 Types of Delayed non-immune reaction

Answer 9

Viral infections

Iron overload