Haematology 7-ordered

Question 1

ive An Overview of the Haemostatic Plug Formation

Answer 1

pg1

Question 2

Explain the importance of the endothelium and the sub-endothelial space in haemostasis

Answer 2

pg 1

Question 3

Describe the origin of the Platelet

Answer 3

pg 3

Question 4

Describe the ultrastructural features of a Platelet

Answer 4

pg 3

Question 5

Describe the process of platelet plug formation

Answer 5

pg 4

Question 6

Describe, and explain where relevant, prostaglandin metabolism that takes place in platelets and in the endothelium

Answer 6

pg 5

Question 7

Describe and explain the use of antiplatelet agents as antithrombotic agents, give examples of names of antiplatelet agents with their mechanisms

Answer 7

pg 5

Question 8

List the tests to monitor platelets and their function, stating the most important.

Answer 8

pg 6

Question 9

What is the normal range for platelet count, describe bleeding patterns at platelet counts outside the normal range, give a description of their causes.

Question 10

Describe what bleeding time and platelet aggregation is used to check and how they are used to check this, describe procedures carried out to check platelet aggregation and platelet count

Answer 10

pg 8

Question 11

Recall the sites of synthesis of coagulation proteins

Answer 11

pg 8

Question 12

Describe the process of the clotting cascade

Answer 12

pg 9

Question 13

Explain the role of platelets in accelerating blood coagulation

Answer 13

pg10

Question 14

Describe, and explain where relevant, the mode of action of warfarin as an Anticoagulant

Answer 14

pg 10

Question 15

1)Explain the Mechanism of Action of Heparin as an Anticoagulant

Answer 15

pg 12

Question 16

List the laboratory Tests for Blood Coagulation

Answer 16

pg 13

Question 17

• Describe what Activated Partial Thromboplastin Time (APTT) ,Prothrombin Time (PT)

and Thrombin Clotting Time (TCT) detects , and how it does this

Answer 17

pf 13

Question 18

Which of activated partial thromboplastin time and prothrombin time is used for screening for causes of bleeding disorders

Answer 18

pg 14

Question 19

Which of activated partial thromboplastin time and prothrombin time is used to monitor heparin therapy for thrombosis

Answer 19

pg 14

Question 20

Which of activated partial thromboplastin time and prothrombin time is used for monitoring warfarin treatment in thrombosis

Answer 20

pg 14

Question 21

Describe the process of fibrinolysis

Answer 21

pg 14

Question 22

Why doesn’t the blood clot completely when the cascade is activated?

Answer 22

pg 15