Haematology 10

Question 1

Give the details of the clinical features of folate and B12 deficiency(30s)

Question 2

Give examples of the groups of people at risk of folate deficiency as a result of decreased intake, and explain the effect of folate deficiency on the body(1)

Question 3

Recall the two main causes of vitamin B12 deficiency).Vitamin B12 is ingested and stored by animals.List sources of vitamin B12. Recall the amount of vitamin B12 that an adult needs per day , and recall the amount that is an hepatic store)(30s)

Question 4

Give details of the structure of a cobalamine molecule(1)

Question 5

Explain what megaloblastic changes in red blood cells and white blood cells are , and the observations that could be made as a result of them(2)

Question 6

Describe what can cause malabsorption of folate(30s)

Question 7

Recall the factors affecting absorption of B12(30s)

Question 8

List the signs and symptoms of B12 deficiency(30s)

Question 9

Explain the Importance of Folate and B12 in DNA Synthesis(1)

Question 10

Give the relevant details for the relationship between homocysteine and thrombosis(30s)

Question 11

Explain how you diagnose pernicious anaemia with auto-antibodies(30s)

Question 12

Recall the tests-which relevant details of each where relevant- that can be used to establish folate deficiency.(30s)

Question 13

Describe the consequences of folate deficiency, give the details of any available guidelines for prevent folate deficiency.(30s)

Question 14

Give the details for the new tests that can be used to check for folate and vitamin B12 deficiency, with a description of the advantages and disadvantages of theses tests where relevant.(30s)

Question 15

which type of food in folic acid found in(10s)

Question 16

Give details of general guidelines for the diagnosis and treatment of cobalamin and folate disorders(30s)

Question 17

Which one of these cases as a cause of vitamin 12 deficiency does not happen

Question 18

• You run out of folate much quicker than B12 T/F(10s)

Question 19

Dietary B12 deficiency is likely T/F. Describe the cases where you would get this.(30s)

Question 20

Describe the consequences of B 12 deficiency(30s)

Question 21

Give the relevant details for the relationship between homocysteine and thrombosis(30s)

Question 22

Folic Acid is required for:(10s)

Question 23

Vitamin B12 is required for:(10s)

Question 24

what is the characteristic of a dysplastic red cell)(30s)

Question 25

Explain why you eventually get a fall in red cell MCV during a megaloblastic change(10s)

Question 26

_To what extent is_ **folate supplementation given in UK and USA ?(30s)**

Question 27

**_Describe the pathway for Absorption of B12 and Folates(2)_**

Question 28

_Describe the test used to establish b12 deficiency, and explain the problems with this test.(30s)_

Question 29

(state the most major sign of macrocytic anaemia due to B12 deficiency(10s)

Question 30

List the three causes of folate deficiency(10s)

Question 31

_Describe what happens in pernicious anaemia. Which age group and sex is it most common in .(30s)_

Question 32

_Describe what can cause an increased demand in folate(30s)_

Question 33

_When analysing peripheral blood films, what is hyper segmentation. Explain how you would identify what an oval macrocyte is.(30s)_

Question 34

_Give the details of the causes of macrocytic anaemia(1)_