Haematology 7 -unordered

Question 1

Describe the origin of the Platelet

Answer 1

pg 3

Question 2

ive An Overview of the Haemostatic Plug Formation

Answer 2

pg1

Question 3

What is the normal range for platelet count, describe bleeding patterns at platelet counts outside the normal range, give a description of their causes.

Question 4

1)Explain the Mechanism of Action of Heparin as an Anticoagulant

Answer 4

pg 12

Question 5

Explain the role of platelets in accelerating blood coagulation

Answer 5

pg10

Question 6

Recall the sites of synthesis of coagulation proteins

Answer 6

pg 8

Question 7

Describe, and explain where relevant, prostaglandin metabolism that takes place in platelets and in the endothelium

Answer 7

pg 5

Question 8

Describe, and explain where relevant, the mode of action of warfarin as an Anticoagulant. In treatment of clots , which particular aspect is it used for.

Answer 8

pg 10

Question 9

Which of activated partial thromboplastin time and prothrombin time is used for screening for causes of bleeding disorders

Answer 9

pg 14

Question 10

Explain the importance of the endothelium and the sub-endothelial space in haemostasis

Answer 10

pg 1

Question 11

Describe the process of the clotting cascade

Answer 11

pg 9

Question 12

Describe the process of platelet plug formation

Answer 12

pg 4

Question 13

Why doesn’t the blood clot completely when the cascade is activated?

Answer 13

pg 15

Question 14

Describe the process of fibrinolysis

Answer 14

pg 14

Question 15

• Describe what Activated Partial Thromboplastin Time (APTT) ,Prothrombin Time (PT)

and Thrombin Clotting Time (TCT) detects , and how it does this

Answer 15

pf 13

Question 16

Describe and explain the use of antiplatelet agents as antithrombotic agents, give examples of names of antiplatelet agents with their mechanisms

Answer 16

pg 5

Question 17

Describe the ultrastructural features of a Platelet

Answer 17

pg 3

Question 18

Which of activated partial thromboplastin time and prothrombin time is used for monitoring warfarin treatment in thrombosis

Answer 18

pg 14

Question 19

Describe what bleeding time and platelet aggregation is used to check and how they are used to check this, describe procedures carried out to check platelet aggregation and platelet count

Answer 19

pg 8

Question 20

List the tests to monitor platelets and their function, stating the most important.

Answer 20

pg 6

Question 21

List the laboratory Tests for Blood Coagulation

Answer 21

pg 13

Question 22

Which of activated partial thromboplastin time and prothrombin time is used to monitor heparin therapy for thrombosis

Answer 22

pg 14

Question 23

Describe the important features of factor 7 and tissue factor

Answer 23

Slide 54-57

Question 24

List the Serine protease domain-containing proteins, describe what they do and their functions. What is significant about them compared to other clotting factors

Answer 24

Slide 57-60

Question 25

_Explain which parts of the coagulation process is initiation and which part is coagulation, state what the role of TFPI and protein C pathway in deal with these parts._

Answer 25

_Slide 60-69_

Question 26

_What does TFPI do_

Answer 26

_Slide 75_

Question 27

_What happens to all the thrombin??_ _What stops coagulation occurring elsewhere??_

Answer 27

pg 21