Haem 3S: Myeloproliferative Disorders (MPDs)

Question 1

Where do myeloproliferative disorders arise from?

Answer 1

MPDs arise from the common myeloid progenitor cell

Question 2

How is haemopoiesis controlled?

Answer 2

• Growth factors (e.g. EPO)
• Receptors (these interact with growth factors → activation of kinases → phosphorylation of intracellular molecules)

Question 3

What is the BCR-ABL gene?

Answer 3

• BCR-ABL is a kinase gene fusion
• feature of CML