ChemPath 3: Sodium and Fluid Balance Flashcards
Define Hyponatraemia
- Serum sodium <135 mmol/L
Which is the commonest electrolyte abnormality in hospitalised patients?
Hyponatraemia
Which hormone regulates water balance?
ADH
Outline how ADH works
- Synthesised in hypothalamus
- Secreted from posterior pituitary, acts on CD in the kidney
- Water retention through insertion of aquaporin 2 (AQA2)
Briefly explain the pathogenesis of hyponatraemia
Which receptors does ADH act on?
What happens once it has bound to these receptors?
V2 receptors in collecting duct –> insertion of AQA2
Where are V1 receptors found?
- Vascular smooth muscle
- Vasoconstriction – higher concentrations
- “Vasopressin”
What are the 2 main stimuli for ADH secretion?
- Serum osmolality (high) – mediated by hypothalamic osmoreceptors
- Blood volume/pressure (low) – mediated by baroreceptors in carotids, atria, aorta
What is the effect of increased ADH secretion on serum sodium?
- ADH only resorbs water, not any sodium
- –> Hyponatraemia
What is the first step in clinical assessment of a patient with hyponatraemia?
clinical assessment of volume status (Hypovolaemia, euvolemia, hypervolaemia)
What are the clinical signs of hypovolaemia?
- Tachycardia
- Postural hypotension
- Dry mucous membranes
- Reduced skin turgor
- Confusion or drowsiness
- Reduced urine output
- Low urine Na+ (<20)
What is the normal range of urine Na?
- Normal range = 40-220 mEq/L [<20 non-renal loss; >20 in renal loss)
What is the issue with using urine Na as a tool for assessing ?hyponatraemia?
- Patients on diuretics may have urine Na that is not reliable (hypovolemic, but no hyponatraemia)
What are the clinical Signs of hypervolemia?
- Raised JVP
- Bi-basal crackles
- Peripheral oedema
What does hyponatraemia in a hypovolaemic patient require?
requires more sodium than water loss