GYN- Hirsituism and Virilization

Question 1

difference between hirsituism and virilization

Answer 1

hirsutism is excess male pattern hair growth while virilization is hirsutism + secondary male sex characteristics (clitoromegaly, deep voice, etc)

Question 2

next step/labs to deetermine etiology of hirsutism

Answer 2

get free T, DHEAS, 17-OHP, cortisol

• elevated T = either adrenal or ovarian source
• elevated DHEAS = adrenal source
• elevated 17-OHP = CAH
• elevated cortisol = cushing syndrome

Question 3

What are the rotterdam critera?

Answer 3

diagnostic criterea for PCOS, need 2/3

polycystic ovarias on US
anovution
signs of hyperandrogensism

Question 4

what tumor can cuase hirsituism

Answer 4

sertoli-leydig cell tumors

Question 5

what cysts can cayse hirsituism

Answer 5

theca leutin cysts

Question 6

overian hyperplasia in postmenopausal women that can possibly lead to androgen production

Answer 6

stromal hyperthecosis

Question 7

how is idiopathic hirsutism diagnosed

Answer 7

normal T and DHEAS

look for increased peripheral 5aR activity

Tx is finasteride (5aR blocker) if periph activity is elevated