GYN Flashcards
what days of cycle are optimal for fertilization
day 11-15
name the two phases (or 3)
follicular (proliferative)
luteal (secretory)
Follicular + menstruation
ovulation
luteal
Follicular phase
- days
- predominant hormone
day 1 (menstruation) to day 14 (ovulation) -new follicle is growing
HORMONES:
*GnRH–>FSH + LH–>follicle grows–>secreting estorgen–>provides (-) feedback to AP–>but then estrogen gets to a point where its very high and creates (+) feedback on FSH and LH—SURGE–. SURGE OF LH=OVULATION
what causes menstruation
progesterone withdrawal
what triggers ovulation
on day 11-14 a sugrge in LH occurs once dominant follicle is selected
corpus luteum
- progesterone production
- —-> neg feedback on FSH + LH
Luteal PHase
-hormone and its role
PROGESTERONE
- enhances endometrial lining to prepare it for implantation
- once there is no implantation– corpus luteum degenerates into corpus albicans —-> steep decr in estrogen + Progesterone
***this drop of hormones leads to menstruation and star of new cycle
MCC of secondary amenorrhea
pregnancy
ALWAYS DO PT IN EVERY PATIENT
primary vs secondary amenhorrhea
PRIMARY
- failure of menses to occur by age 15 (or 16) in presence of normal growth and secondary sexual characteristics
- ->start evaluation at age 13 if no menses + absence of secondary charactersistics
SECONDARY
*absence of menses for 3 MO in a woman with previous menses
oR
6 months in a woman with hx of irreg cycles
causes of primary amenorrhea
Turners syndrome—- XO
hypothalamic-pituitary insufficiency 46 XX
*low FSH low LH
Androgen insensitivity: 46 XY
High testosterone… breast development only
Imperforate hymen: 46, XX, diagnosed on PE
anorexia
mullerian agensis– no uterus but has secondary sex charactersitcs
Turners syndrome
XO
webbed neck, broad chest, high FSH
causes of secnoadry amenhorrhea
-what hormones to always check
pregnancy
hypothyroid
weight changes
prolactinoma
**ALWAYS CHECK BHCG, TSH and Prolactin
***progesterone challenege test–> medroxyprogesterone 5-10 mg PO once a day or another progesterone for 7-10 days—— if bleeding occurs=anouvulatory cycles
MCC of primary amenorrhea
GONADAL DYSGENSIS
- Turner syndrome– 45XO
- Mullerian dysgenesis– 46XX
- Androgen Insensitivity—46XY
a 35-year-old woman with concerns about heavy menstrual periods for the past year that occur at irregular intervals. She explains that sometimes her menses come twice a month but other times will skip two months in a row. Her menses may last 7 to 10 days and require 10 to 15 thick sanitary napkins on the heaviest days. PELVIC EXAM NORMAL NORMAL PAP no STIs
DUB
define DUB
excessive uterine bleeding with prolonged menses that is NOT CAUSED BY PREGNANCY OR MISCARRIAGE
**diagnosis of exlcusion
define Polymenorrhea
menses that occur more frequently (<21 days apart menses)
define hemorrhagic or hypermenorrhea
menses that involve more blood loss >7 days or >80 mL
menorrhagia
prolonged/heavy bleeding
>7 days or >80 ml at regular intervals
metrorrhagia
uterine bleeding that occurs frequently and irreguarly b/w cycles
menometrorrhaiga
more blood loss during menses and frequent and irregular bleeding b/w menses
oligomenorrhea
long intervals of >35 days
MCC of AUB/DUB
chronic anovulation
**corpus luteum does not form–>so noprogesterone formed—>unoppposed estrogen–>endometrial overgrowth–>irregular, unprediactable shedding
GS for diagnosis of AUB
uterine D/C
labs to order for DUB
bHCG
CBC, iron stuidies, PT, PTT,
TSH, progesterone, prolactin, FSH,
LFTs
how to confirm anovulatry cycle causing DUB
progestin trial– if the bleeding stops its from anovulation
TX for AUB
OCPs
NSAIDs
TX for AUB
OCPs
NSAIDs
TX for AUB
OCPs
NSAIDs
TX for AUB
OCPs
NSAIDs
TX for AUB
OCPs
NSAIDs
TX for AUB
OCPs
NSAIDs
TX for AUB
OCPs
NSAIDs
TX for AUB
OCPs
NSAIDs
a 19-year-old nulligravid college female who complains of dull, throbbing, cramping lower abdominal pain during menses for the past three years. She reports nausea and vomiting during menses but denies irregular or heavy periods, pain with intercourse, or abdominal pain outside of menses. Pain tends to peak 24 h after the onset of menses and subsides after 2 to 3 days. A pelvic exam is norma
dysmenorrhea
define dysmenorrhea
uterine pain around time of menses
difffernece b/w primary and secondary dysmenorrhea
RF for both
tx for both
PRIMARY -no organic cause -pain from excess of prostaglandins -teens to early 20s--- declines with age -NO Pelvic pathology -N/V/D -HA "labor like pains"
RF
- menarche before 12
- nulliparity
- smoking
- fm hx
- obesity
TX= NSAIDs, OCPs
SECONDARY from pathologic cause
- endometriosis
- adenomyosis
- polyps
- fibrids
- PID
- IUD
- tumors
- adhesions
- cervical stenosis
- lesions
- psych
- *pain will increase in severity until end
- common in age 20-40s
tx=underlinyg cause
avg age for menopause
44-55
avg=51
perimenopause
transition period b/w reproductive capability and menopause
hallmark=irregular menses 3-5 years
onset of menopause <40 YO
premature ovarian failure
labs seen in menopause
elevated FSH >30 + low estradiol
**high FSH not requried tho its mainy about amenorrhea for 1 yr
tx for menopause
+uterus
-uterus
+uterus: HRT—-estrogen + progesterone
HRT=hormone replacement therapy
**Tibolone
-uterus----ERT (just estrogen) ERT=estrogen replacement therapy or SERMS-----selective estrogen receptor modulators *******raloxifine ******tamoxifen
why can you not use estrogen alone for woman in menopause with intact uterus?
incrs risk of endometrial CA
and DVT/PE
Risk of Tibolone or any HRT
BCA but its low
contraindication for HRT
hx of BCA
HRT effect on lipid profile
incrs HDL and TG levels
decrs LDL
contras for HRT
high trigs undiagnosed vag bleeding endometrial CA hx of bCA or estrogen sensitive CAs CVD hx DVT or PE
define premenstrual dysphoric disorder (PMDD)
repeated epsiode of significant depression and related s/s during week b4 menses
*****severe/debilitating PMS
DSM-5
- at least 5 symptoms in final week b4 menses
- that imrpove within few days after onset of menses
- becomes absent or minimal week post menses
S/S:
- marked lability—-mood swings, feeling suddenly sad or tearful, incrs sensitivity/rejection
- marked irriability
- depression
- severe anxiety
tx for PMDD
SSRIs
-fluoxetine or sertraline
SNRIs
-venlafaxine
low dose OCPs + diuretics
GnRH—- only as third+ line
Benzos, TCAs,
SEVERE/REFRACTORY
-ovarianectomy
when do s/s o PMS occur in cycle
-when do s/s resole
luteal phase (1-2 wks before menses)
resole at onset of menses
tx for PMS
exercise
stress reduction
1st line- SSRIs if they dont want OCPs
OCPS will be first tho before SSRIs
mucopuruelnt discharge
gram neg diplococci
gonorrhea
MC women are asympto
tx gonorrhea
IM ceftriaxone 500 mg if <300 pounds
>300 piunds= 1 gram ceftri IM
***usually tx as co infection
urethritis, vulvovaginitis (vulvar and vaginal discomfort, pain, pruritus), and inflammation of the cervix; clear vaginal discharge
chlamydia
tx for chlamydia
doxycycline 100 mg BID 7 days
alternatives
-azitrhomycin 1 g PO x1 dose
OR
-levofloxacin 500g PO x 7 days
mc sti
chlamydia
GS dx for HSV
viral culture
tx for HSV
**valcyclovir
which type of HPV MC cause for cervical CA and anal CA
16 and 18
which type of HPV causes warts
6 and 11
Gardasil covers which HPV strains
6
11
16
18
31 33 45 52 58
> 90% of cervical cancer is associated with HPV types
16 18 31 33 35
_____ is commonly seen in combination with condylomata acuminata
trichomonas
PAP shows koilocytic squamous epithelial cells in clumps
cervical warts from HPV
when does HPV vaccine start
9
oldest you can be to get HPV vaccine
45
painful sore on her vulva that first resembled a pimple. On examination, you find an ulcer with clearly demarcated borders, gray base, and foul-smelling discharge.
chancroid
YES its a STI
causative pathogen for chancroid
Haemophilus ducreyi
gram - ROD
in half of PT with chancroid there will also be?
marked lymphadenopathy in inguinal chain
tx for chancroid
single does IM ceftri 250 or azitrhomycin 1 grams PO x1 dose
serotypes of chlamydia tht cause chalmydia
D-K
serotypes of CT that cause lymphogranuloma venereum (LGV)
L1-3
RF for LGV
MSM– unprotected anal sex, HIV, HCV
painless genital ulcers or papules
lymphogranuloma vanereum
uni or bilat tender inguinal and or femoral lymphadenopathy
lymphogranuloma vanereum
strictures, fibroisis and fistulae of anogenital region
lymphogranuloma vanereum
tx for lymphogranuloma vanereum
doxycycline 100 mg PO BID for 21 days
PID involves what parts
infection ascending from cervix or vagina INTO ENDOMETRIUM AND/OR FALLOPIAN TUBES
tx for PID outpatient
ceftriaxone IIM 250 mg once + PO doxycycline 100 mg BID x14 days +/- PO Flagyl 500 mg BID x14 days
when to admit for PID
sevee n/v
if diagnosis is uncertain
ectopic preg and appendicity cant be ruled out
preg or pelvic abscess suspected
HIV+
cannot tolerate outpt meds
faiil to respond to outpt meds
inpatient tx for PID
IV second gen cephalosporin (cefoxitin or cefotetan) + IV Doxy—-then PO doxy for 14 days
clindamycin + gentamycin is alternative—– use this in pregnancy or pcn allergy—- then use PO doxy
sypgilis causative agent
spirochete Treponema pallidum
painless single ulcer (chancer)
syphilis
erythematous rash invovling palms and soles
+/- condyloma lata
secondary syphilis
what can cause a false negative syphilis test
lyme disease