Gut Microbiology Flashcards
GI Infections can be divided into three distinctive types - what are they?
Non-inflammatory
Inflammatory
Penetrating
Where are non-inflammatory GI infections commonly located?
Proximal small bowel
Where are inflammatory GI infections commonly located?
Colon
Where penetrating GI infections commonly located?
Distal small bowel
Why are ABX rarely useful for treating Gastroenteritis?
Make Campylobacter jejuni worse by releasing further toxins, causing diarrhoea
What bacterial disease is commonly associated with Reptiles?
Salmonella arizonae
Which Ig is a host defence against GI Infection?
Secretory IgA
What are the three main types of MALT (Mucosa associated lymphoid tissue)?
BALT - bronchus ALT
GALT - gut ALT
NALT - nasal ALT
The appendix is a large source of immune activity due to the presence of..?
MALT
How might the appendix help if ABX were to wipe out all the gut flora?
The appendix contains copies of all gut flora to allow re-population
What 4 antibiotics commonly facilitate C. diff overgrowth?
4 C’s
- Clindamycin
- Cephalosporins
- Ciprofloxacin
- Co-amoxiclav
How is C. diff detected? Why aren’t stool culture used?
Toxin detection
Stools aren’t used routinely because sensitivity is low and asymptomatic carriers aren’t picked up
Give examples of 2 anti-C.diff antimicrobials used to treat a C.diff infection
Oral Metronidazole
Oral Vancomycin
Aside from Oral Metronidazole and Oral Vancomycin, what non-drug treatments can treat a C. diff infection?
Probiotics i.e. Saccharomyces cerevisiae
Faecal floral transplant
State the name of one autism-associated bacterium
C. Boltiae
