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Derm > Guo - Pathology > Flashcards

Guo - Pathology Flashcards

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Dermatology Board Prep flashcards
1
Q

CD4+ Th1 cells release cytokines in which skin layer?

A

Dermis

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2
Q

Which cytokines are released from CD8 cells?

A

IL-17
IL-22 and
IFN gamma

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3
Q

Melanoma ABC’s

-A

A

Asymmetry

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4
Q

Melanoma ABC’s

-B

A

Border irregularity

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5
Q

CD8 cells release cytokines in which skin layer?

A

Epidermis

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6
Q

Melanoma ABC’s

-C

A

Color

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7
Q

Melanoma ABC’s

-D

A

Diameter: 1/4 inch or 6mm

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8
Q

S100
HMB45
Melan A

A

Melanoma panel

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9
Q

With melanoma, don’t ever miss this!

A

Atypical mitoses

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10
Q

Form of melanoma associated with poor prognosis

A

Nodular

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11
Q

Melanoma type often misdiagnosed due to rapid growth and lack of pigmentation (melanoma gets pale with metastasis)

A

Amelanocytic melanoma

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12
Q

Melanoma type with Positive S-100 but negative for other melanoma markers.

A

Desmoplastic melanoma

head,neck and high recurrence

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13
Q

More than 100 widespread nevi, high lifetime risk of melanoma

A

Familial atypical multiple mole and melanoma syndrome

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14
Q

Surface of a pearly nodule that crusts off and exposes dilated subepidermal blood vessels and starts bleeding

A

Basal cell carcinoma

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15
Q
  • Basaloid tumor islands
  • Peripheral palisading of nuclei
  • Stromal retraction artifact
A

Basal cell carcinoma

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16
Q

When in doubt of Basal cell carcinoma, do this

A

IHC for tumor markers

17
Q

Tadpoles in dermis

A

Syringomas

18
Q

Flesh-colored small papules surrounding eye

A

Syringomas

19
Q

Basaloid cells boring primitive hair follicles and keratinous cysts

A

Trichoepithelioma

*He said know the hits slide for this one (slide 48)

20
Q

Turban tumors

A

Cylindromas

*benign, but awful looking

21
Q

Dark brown lesions
Greasy looking
Sharp edges

A

Seborrheic keratosis

22
Q

Could mean gut cancer

A

Leser-Trelat sign

23
Q 
3Ps
-purple
-pruritic
-polygonal papules
(saw-tooth elongation of rete ridges)
A

Lichen planes

24
Q

Tombstone row of basal layer keratinocytes and acantholysis of epidermis

A

Pemphigus vulgaris

25
Q

IgG autoantibodies to desmoglein 3. Immunoflouescence is chicken wire pattern

A

Pemphigus vulgaris

26
Q

Clinical features:

  • linear IgG along basement membrane (immunofluorescence)
  • Chronic autoimmune blisters
  • 60-80yo
  • cutaneous and mucosal
A

Bullous pemphigoid

27
Q

Clinical features:

  • intensely pruritic papulovesicular eruptions
  • Symmetrical distribution on elbows, knees, buttocks
  • 20-60 yo
  • male>female
A

Dermatitis herpetiformis

*gluten sensitivity

28
Q

Histological features:

  • neutrophil rich sub epidermal bulla
  • Granular IgA in papillary dermal tips (immunofluorescence)
A

Dermatitis herpetiformis

29
Q

Blue stained elastosis sun damage on histo slides

A

Squamous cell carcinoma

Derm (10 decks)

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