Aanderud - Vasculitis Flashcards
This size is the most common of the vasculitises
Small
Inflammation involving the respiratory tract and necrotizing vasculitis affecting small to medium-sized vessels; necrotizing glomerulonephritis is common.
Wegners Granulomatosis
*Granulomatosis with polyangiitis
C-ANCA positive
Wegners
P-ANCA positive
Churg-Strauss
Tx for Wegners Granulomatosis
Cyclophosphamide
Eosinophil-rich and granulomatous inflammation involving the respiratory tract, necrotizing vasculitis affecting small to medium sized vessels. Associated with asthma and eosinophilia
Churg-Strauss
Saddle nose deformities, and palpable purpura in mouth, tongue, nose (red nodules)
Wegners
*(with Polyangiitis)
Treat C-ANCA positive with what drug?
Cyclophosphamide
*C and C (Wegners)
Ridiculous amount of peripheral eosinophilia
Churg-Strauss
*(Eosinophilic Granulomatosis with polyangiitis)
IgA immune deposits surrounding blood vessels. Kids. Type 3 hypersensitivity rxn.
Henoch-Schonlein purpura
Kids’ vasculitis affecting small vessels. Usually involves skin, gut, glomeruli. Complaints = HA, joint pain, blood in urine, widespread red rash. IgA deposits
Henoch-Schonlein purpura
Purpura on extensor surfaces and buttocks
Henoch-Schonlein purpura
What test do you order if you suspect autoimmune dz like
ANA
What do you do if u suspect a vasculitis?
Get the biopsy, get the blood work, Tx with oral steroids, refer to derm
Name the hypersensitivity type:
-Anaphylactic
Type 1
Name the hypersensitivity type:
-Immune reactions
Goodpastures
Membranous nephropathy
Type 2
Name the hypersensitivity type:
-Delayed rxns
PPD
Transplant pts
Type 4
Name the hypersensitivity type:
- Autoantibody immune complexes
Type 3
Order this test if you’re worried about a connective tissue disease
ANA
*Antinuclear antibody screening
T/F?
-Lupus is sensitive to Light
True
This lupus type causes horrible facial and scalp scarring
Discoid
If mom has lupus and you’re scared baby has lupus, what should you test for?
Anti - Ro
*To prevent heart block
Drug induced caused by which agents?
Hydralazine
Procainamide
Isoniazid
*Resembles acute lupus
What is the following workup appropriate for?
-Blood work, biopsy, topical steroid, refer to derm
Lupus
Heliotropic rash Gottron's papules Periungual erythema Periungual telangiectasia Violaceous scaling patches kids with Calcium deposits in skin
Dermatomyositis
Antibody tests for Dermatomyosits
ANA
Jo-1
SS-A (Ro)
Weak proximal leg muscles = trouble getting out of chair
Dermatomyositis
Anti scl70
Scleroderma
