GU Flashcards
testicular cancer
- common in 15- 35 men
- RF: undescended testicles
seminonam and nonseminoams
presentation: painless testicular mass
- mets signs ( brain mets, retroperitoneal mets)
labs;
nonseminomas- very high bHCG, AFP, LDH
seminomas: slight high bHCG, non-elevated, elevated LDH
imaging: scrotal sonogram
surveillance for mets and brain
tx: radical orchiectomy for every one
seminona- rad tx with chemo
nonseminona- no rad tx
chemo tx
px: excellent
prostate cancer
adenocarcinoma , AA,
fix
s/s: 2/3 asymptomatic when diagnosed
- rectal exam: hard and nodule
advanced dz: specific to mets ( does, nodes, rectum, and bladder)
labs: PSA> 4.0 good for monitoring and following pt with cancer
changed recs; over dx of cancer and tx
PSA can be high with other cancers
transrectal us/ guided bx
- do for anyone with positive DRE
Gleason score: evaluate tissue sample
tumor surveillance: CT abdomen/ pelvis, bone scan, MRI
tx: active surveillance
radical prostatectomy
rt and androgen therapy( luron, orchiectomy, anti-androgen)
cryotherapy
screening: Lots of disagreement
- need to screen in AA and fix
bladder cancer
linked to manufacture (leather, rubber, cig smoking, dyes)
transitional cells
- s/s: painless hematuria
labs: UA
studies; bx
tx: how much penetrattion of bladder wall
Transurethral resection with fulguration with chemo IP - Ta/ T1
invasive bladder: radical cystectomy with pelvic lymphadectomy chemo/t x
renal cell carcinoma
- occlusive thrombi in renal veina
- associated with paraneoplastic syndrome
- diagnosed on incidental scan
s/s: flank pain with hematuria
dx: CT scan and met work up
labs: check LFTs, CBC, CMP
tx: radial partial nephrectomy with met ( lung, bones, and brain --> poor px
wilms tumor
2-3 y/o
tumors in the kidneys
palpable ab mass, and pain, and hematuria
cannot bx- spill tumor cell and increase stage
tx; surgical resection, nephrectomy, chemotherapy, rad tx
px: depends on histology
acute renal failure
- sudden rise in BUN/Cr
- build up of nitrogenous waste
s/s: uremic ( nausea/ itching)
labs: BUN/Cr
causes: pre renal azotemia, intrinsic renal ( failure, post renal azoetmia
major cause: pre-renal azotemia
- volume deplete
- septic
- no blood flow to kidneys
tx: tx the cause
monitor K
post renal azotemia-
bilat obstruciotn
acute tubular necrosis
- damage of renal of tubules
- muddy sediment, granular case
cause: MI, sepsis,nephrotoxic, IV constrast
tx: tx the cause, low protein diets, dialysis
- can repair itself
interstitial nephritis
inflame of renal tubules
causes:
drugs
s/s : fever, rash, arthalgias
labs: WBC casts and eosinophils
tx: remove cause
steroids
dialysis
-pts get better
glomerulonephritis
inflame of glomerulus from immune complex deposition
Immune complex- strep in kids
- tea colored urine
- puffy on eyes and scrotum
- positive ASO titer
IGA nephropathy- starts with URI or H. flu and have hematuria
lupus nephritis- auto ab production
+ ANA and ANCA
Good Pasteur syndrome: assoc with pulmonary hemorrhage
tx: plasmapheritis
Vasculitis: effects small and medium sized vessels
- assoc with granuloma formation airway, lung skin,
Rhinitis
Vascular: hemolytic uremic syndrome
-uremia, low plts, hemolytic anemia
s/s: hematuria, HTN, edema, tea colored urine with RBC casts
dx: renal bx
tx: steroids except for post strep pt
Good pasteur- plasmapheresis
chronic renal failure
destruction of nephrons least to progressive decline
causes: HTN and DM
dx: HTN, high BUN/ Cr, SOB
UA: proteinuria, U/s shows small echogenic kidneys
tx: renal diet, dialysis
and or transplant
ACE or ARB to delay progression
nephrotic syndrome
increased permeability of glomeulr capillary walls ) glomeulr becomes a sieve) proteinuria, hypoalbuimnaea and edema causes: primary minimal change dz membranous nephropathy
dx: proteinuria > 3 gm
oval fat body( Maltese cross)
management: low ptn diet, restrict salt, tx of hyperlipidemia, anemia
diuretics and ACE inhibitors
polycystic kidney disease
hereditary dz ( 30s and 40s)
clinical features: cross hematuria, abd flank pain,
complications: cysts rupture, stones, HTN, Cerebral aneurysms, aspirate cyst
tx: agressive HTN tx,
renal transplant
rental artery stenosis
HTN 50
abd exam: renal bruit
if you give ACE–> creatine goes up
dx: renal arteriography
tx: renal artery angioplasty with stunting
renal vein thrombosis
causes: children - severe dehydration
adults: infection, ascending thrombus of v. cava
sxs: flank pain and palpable kindness
dx: renal us, renal venography
tx: eliminate cause, anticoagulant or thrombolytic
hypnatremia
-affect CNS
- low sodium
- total body watery and total body sodium
-
SIADH
- brain produces ADH despite normal plasma volume
- causes: trauma, strok, small cell lung ca
labs: Urine:
tx: fluid restrict, and tx the cause
hypernatremia
Na> 145 mEq/L
Causes: impaired thirst, lack of access to water, lactulose and mannitol
s/s: dehydraiton, hyperthermia, delirium
tx: volume replacement and dehydration
Decrease serum sodium by no more than 1 meQ/:
too fast–> neuro edema
diabetes insipidus
problem wth ADH
central DI: head injury
nephrogentic- kindney not listening to ADH
dx: water deprivation test (
tx: volume replacement for everyone
central: desmopression
nephrogenic ID: treat underlying cause