GI Flashcards

1
Q

infectious esophagitis

A
  • immunocompromised
    RF: AIDS/DM/steroid
    -odynophagia/ dysphagia
Dx: endoscopy
- find ulcers and deep- CMV
-shallow and numerous- HSV
white plaques- candida 
tx: specific for infection 
(look for immunocompromised, sarcoid on steroids, )
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2
Q

pill induced esophagitis

A
  • pt on NSAIDS or ab
  • tetracycline and bisphosphate

s/s: odynophgia/ chest pain

diagnostic: endoscopy: varied findings
tx: preventing, remove offending agent

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3
Q

achalasia

A
  • global motor disorder
  • 30- 60 years
  • gradual to solid an the liquid
    -pathophys: recent viral infection, autoimmune
    s/s: regurgitation of foot
    ,extend neck

diagnostic: barium swallow
- bird peak pattern

tx: botox, pneumatic dilatation , and surgery

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4
Q

scleroderma

A

CREST- calcinosis, raynauds, esophageal dysmotilty
- esophagus affected

s/s: severe GERD to sold and liquids
dx: barium swallow
manometry

tx; PPI and protons

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5
Q

esophageal spasm

A
  • not understood
  • low nitric oxide

clinica; chest pain/ dysphasia

dx: corkscrew esophagus on barium
tx: nitrates , TCA antidepressant

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6
Q

zenker’s diverticulum

A

pouching in the upper esophageal

s/sx: food bolus suck in diverticulum, halitosis, GERD hours after eating

dx; barium swallow, dysphagia to solids or liquids

tx; asymptomatic - no tx

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7
Q

mallory- weiss tear

A
  • self limited, tear in GE junction
  • hematemesis- bright ted
  • forecful vomiting

-ETOH

dx; generally clinically

tx: most heal w/in 48 hours
- endoscopic epi/theraml coagulation

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8
Q

esophageal neoplasm

A

squamous cell- exogenous
males
s/s: 50- 70 y/o M with h/o ETOH and smoker

adenocarcinoma- Barett’s and obesity

clinical features; dysphagia > solids with wt loss

  • pneumonia/ voice hoarseness
  • chest pain

dx: barium study then endoscopy
tx: surgery
px: 5 year survival rate

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9
Q

esophageal strictures

A

complication of GERD/esophagitis

s/s: dysphagia to solid food over month/ years

dx: biopsy

tx; endoscopic dilatation
long-term PPI
refractory: endoscopic triamcinolone

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10
Q

esophageal varices

A
  • most common of UGIB secondary to portal HTN

NSAIDs makes them worse

  • RF to incr bleeding:
    size of varies, red wale markings, liver dz, active ETOH use

s/s: bleeding

dx: clinical

tx: hemodynamic stability:fluids/ blood products
2 large bore IV, blood products

pharm: octreotide- vasoactive ( to dec splenic blood flow)
vitamin K- abnormal PT
lactulose; encephalopathy
abx prophylaxis

tx: endoscopic evaluation
sclerotherapy
mechanic tamponade

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11
Q

GERD

A

reflux of stomach into esophagus
RF: ETOH, caffeine, obesity, smoking

clinica features: heart burn
ches pain/halitosis/cough

alarm sx;
refractory heartburn, dysphagia, wt loss, GI bleed
45 y/o w/ new onset sxs

tx: LSM-
occ heartburn sxs; antacids

Pharm: PPI
prilosec, prevacid, protons

if pt- GERD sxs and on PPI and no relief–> switch to bid

if bid PPI–> endoscopy

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12
Q

Gastritis

A
  • reflux- bile/ pancreatic juices

hemorrhage- ICU/ burn

Atrophic: risk for gastric CA, pernicious anemia, autoimmune

Infectious: H. pylori

d/dx: dyspepsia/ abd pain

dx; endoscop+ bx , urea breath test

tx: remove offending agent

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13
Q

H. pylori

A

abd pain and nausea
PE: normal

dx; urea breath test ( most sensitive)** fecal assay
endoscopy-

tx: 1st line: PPI+ amox- clairtho

quadruple therapy

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14
Q

Peptic ulcer dz

A

M> W
duodenal > gastric

Risks: smoker/ long-term NSAID

2major causes: chronic NSAID use and H.pylori infection

s/s: epigastric pain

duodenal: improves with food
gastric: worsens with food

dx: upper endoscopy
tx: avoid irritating factors, combo tx, misoprostol

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15
Q

Gastric cancer

A

50-70

adenocarcinoma
M:F : 2: 1

RF: familial / blood group A
-enivormental: H. pylori /smoking/ low SE

s/s: early: no sxs

later: cachexia, dyspepsia, wt loss, GIB
Virchow’s nodes, Sister May joseph nodule, krukernberg tumor

dx: endoscopy and bx
> 55 y/o and failed antisecretctomy tx–> scope

tx: 30% of its- surgery= curative
combo chemo with rad tx improves survival

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16
Q

gastric lymphoma

A

non-hodgkin b cell
-h. pylori RF

s/s: same as adenoma

dx: endoscopic bx
tx: combo chemo w/wo radiation

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17
Q

Gastric neoplasms: ZES

A

-ZE ( gastronome)
refractory PUD
1/3 with MEN-1

s/s: PUD sxs refractory tx

  • heartburn 20%
  • fecal fat diarrhea

dx: fasting serum gastrin levels

tx: PPIs
surgical: curative before hepatic spread

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18
Q

cholelithiasis/ cholecystitis

A

-cholesterol sones
f>M
bilirubin- SS, hemolytic anemia,

RF: age, obesity, rapid wt loss, insulin resistance

s/s: biliary colic, n/v, murphy’s sign, inhibit inspiration, fever

dx: leukocytosis, elevated LFTs amylase/ lipase= pancreatitis
RUQ sono
-HIDA : no filling in cholecystitis

ERCP : indicated biliary obstruction

tx: medical, ( biliary colic)
IV fluids, bowel rest, abx
( ampicillin+ aminoglycoside)

pain management: morhpoine

tx: surgical: laparoscopic
dissolution therapies

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19
Q

choledocholithiasis/ cholangitis

A
  • common bile duct stones
  • RF: infection, biliary stasis, s/p cholecystectomy

Most common cause? acute bacterial cholangitis
-E.coli, Klebsiella

Charts triad: RUQ pain, fever, jaundice

Reynold spread:
charcots triad+ AMS + hyptnsion

dx: initial RUQ sono
Gold standard: ERCP

tx: GB stones present:

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20
Q

primary sclerosis cholangitis

A
  • think UC
  • biliary fibrosis and thickening

sx: jaundice, itching, anorexia, fatigue, indigestion
dx: elevated alk phos

tx: cipro
liver transplant

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21
Q

acute viral hepatitis

A

acute or viral

causes: viral, toxins ( ETOH, tylenol)

acute viral hep:

A and E - self limited
-B/C/D- - parental infections
s/s: fatigue, malaise, anorexia, RUQ pain,

PE jaundice/ RUQ tenderness

acute viral hep

hep A IGM

Hep b: 4 markers
acute hep b infections
- + HBsAg
\+ I gm Anti Hbc
- Anti- Hbx

Immune to Hep B vaccine:
- HBsAg
- Anti- HBcAg
+ Anti- Hbs

Immune due to natural infection :
- HBsAg
+ Anti-HbcAG ( IgG)
+ Anti-HBs

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22
Q

Acute viral hep

A

RNA virus
-recheck in 1 month

Hep D- Anti- HDAb, RNA

Hep E: Anti-HEV Igm ab

tx: Hep A/E- self-limited
Hep B- based on HBeAg- entecavir/ tenofovir/peg-iif

Hep c: peg-interferon/ ribacvarin
- needle stick : monitorRNA/ LFt’s A 2 weeks

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23
Q

acute viral hep

prevention

A

hep a- vaccine- endemic areas, travelers, HCP, chronic liver dz

hep b vaccine: 0.1. 6

Hep c: follow standard precautions/ no vaccine exists

hep D: hep b vaccine

hep E: public hygiene

24
Q

chronic viral hepatitis

A

hep B, C, D
RF for cancer

s/sx: fatigue, nausea, jaundice, RUQ pain, dark urine, itching, wt loss

labs: ALT/AST 2-5 X norma
ALT> AST

tx: hep b- peg-interferon
hep c: curable: ribavirin+ peg IFN

Hep d- high dose PEG IN

25
cirrhosis
irreversible fibrosis - cause: hep c, ETOH liver diz 2 main complications: portal HTN, liver insufficiency s/s: weakness, fatigue, weight loss, PE: enlarged liver, muscle atrophy, spider angiomata late dz; ascites, ecephaltis dx: low albumin, anemia., high alk pos, ascites, low plts tx: stop drinking and hepatic drugs -ascites- salt restrict varices; propanolol octreotie encephalopathy bacterial peritonitis - lactulose - TIPS surgery: liver transplant
26
liver cancer
bening: cavernous hemangioma - hepatocellular adenoma -liver is most common site from lung /breast RF: viral hep, cirrhosis, aspergillus s/sx: anorexia, cachexia, abd pain, wt loss dx: AFT> 200 , 95-100% specificity CT/MRI with contrast need bx no recommended for resectable tumors. tx; bening- avoid trauma, surgical resection if early -liver transplant.
27
acute pancreatitis
most common cause; gallstone and ETOH abuse s/s: ab pain ( epigastric, boring radiating to back), n/v tachycardia hypotension Grey-Turner- flank ecchymosis Cullen sign: umbilical ecchymosis dx: labs: amylase 3x normal value - elevated WBC Ransons' Criteria: - incr mortality with each additional factors imaging: CT more accrue
28
Ranson Criteria
``` on admission: age> 55 WBC> 16, 000 Glucose> 200 LDH> 350 IU/ L SGOT> 250 IU/ L ```
29
acute pancreatitis
npc, pain management( dilaudi), fluid resuscitation, n/v ( pheneragn), zofran when to progress to solid diet--> she appetite, enzymes better
30
chronic pancreatitis
- irreversible permanent fibrosis - secondary to ETOH abuse Classic triad: pancreatic calcification/ steatorrhea/DM s/s: abd pain dx; high fecal fat( ADEK, fat soluble vit) DM pancreatic calc tx; definitie: treat underlying cause - analgesics: tramadol pancreatic enzyme steroids if autoimmune
31
pancreatic ca
genetic predisposition, smoking, most in head of pancreas s/x: abd pain, n/v, diarrhea, wt loss, jaundice dx; labs: anemia, impaired glucose tolerance, steatorrhea Imaging: Ct scan tumor marker: Ca 19-9 tx: no mets: surgery then chemo - unresectable tumor: chemo+ rad tx mets: managed pain/ complications
32
appendicitis
most common acute abs surgery - fecolith ``` s/s: abd ain peri-umbilical pain McBurney's- 1/2 belly button and SI posts sign- raise right leg -obturator sign- have hip and knee flex and internal rotate hip ``` dx: CT scan tx: laparoscopic appendectomy abx: cefotean/ ticarcillin-clavulanate if perforation: rocephin/
33
celiac dz
inlamm condition of small intestine - RF: HLA DQ2, high risk groups: 1st degree relative, Type 1 d s/s: wt loss, diarrhea, abd distention, dermatitis herpetiforms dx: Iga enomysia ab Ina tTg tx; institue gluten-free diet -supplement: vitami D,calcium, b12 , folate bone density studies
34
constipation
-happens and women - 1st step in eval: causes: inadequate fluid/ fiber intake, poor bowel habits secondary etiology; medication, SE dx: colonic transit studies tx: d 30 g fiver okay to take osmotic laxative complication: fecal impactions dec appetite, abd pain, and dissension tx: saline/ mineral oil enema - digital disimpaction -maintain soft bowel movements
35
diverticular dz
- uncomplicated mucosa/ submucosa herniating - western diet - sigmoid colon - high fiber diet, fiber supplements s/s: LLQ pain, fever, anorexia dx: elevated WBC , CT scan barium study colonoscopy-wait till sxs better tx: uncomplciationed: cipro/ levaquiin and flagyl unresponsive - admit _+ IV abx complication--> surgical drainage
36
inflammatory bowel dz
UC and Crohns dz RF: cig smoking, fan hx, Ashkenazi jewish crohns- skip lesions UC: continous dz, curative ( total colectomy), hematochezia extra intestinal: join pain dx: if pt having acute flair up --> no colonoscopy bx: Crohns- cobblestone UC: diffuse leions tx: reduce inflaamm and maintain clinical remission 5-ASA- Asacol, pentasa flair up: abx, steroids refractor dx: immunomodularots abx for acute flair up- cirp, levquin, surgery: crohns' incr risk for colon cancer- screening colonoscopy every 8-10 years
37
IBS
- bening - recurrent abd discomfort ( improved with defecation) - F> M - associated with menses/ stress s/s: anemia, wt loss, fam hx, PE: normal tx: fiber therapy, antispasmodics, antidepressants, cognitive therapy
38
intesintal ischemia
older age, arterial embolus, arterial occlusion, low flow states, extensive surgery, most common side: SMA s/s: acute pain out of proportion -chornic if developed collateral circulation, eat and with pain dx: labs, plain film, angiography tx: volume replacement, abx, gangrene ( OR)
39
colon polyps
- being- non adenoma malignant- adenoma sessile, flat, penduculaeted bening: 90% of large bowel adenoma: > 2 cm has high RF removing adenomatous polpls lower risk for tx: flex sig only finds some but colonsopy was better
40
CRC
- cecum most common - age, fhx, familiar polyposis, UC s/s; slow grwoing, low H/H, fatigue/ weakness, hematochezia, tenesmus, urgency dx: colonoscopy, barium enema CT screening: colonoscopy q 10 years, ( 50-75) FOB/ FIT annually RF: if 1st degree relative began screening at 10 years young or 2 relative every 5 years tx: resection,chem otx chemoprevention: ASA, fruits/ veggies
41
small bowel obstruction
causes: adhesions, hernias s/s: early: diffuse, crampy colicky pain, ab pain, hyperactive BS late: steady abd pain, better localized, quite BS dx; abd xray- dialated loops CT scan tx: nGT, IV flids, pain mets surgery for strangulated source
42
large bowel obstruction
slow in presentation - cause: neoplasm. s/s: abd distension, anoreain, vomting Late: vomit poop dx: ab cry Ct scan tx: surgery more likely with LBO
43
toxic megacolon
thumbprint on ab xray EMERGENCY cause: abx, US, Crohns s/s: fever, abd cramping, distension, rigid belly dx: abd xray, colonic dilation > 6 cm tx; abx, NG suction to decompress colon, IV fluids, surgery
44
hernias
-reducible- blood flow okay and bring back into abd cavity reducible: able to return to contents incarcerated; contents cannot be returned strangulated: incarcerated hernia with compromised blood supply types: umblinia, hiatal, incisions, inguinal, femoral s/s: no sxs, pain with stating or lifting, constant discomfort with incarceration tx: surgery `
45
anal fissure
affects young adults - posterior midline - any fissure off midline should be cancer, syphysiila, crowns, HIV s/s: based on Hx and PE triad: fissure,sentinel skin take and hypertrophic anal paella tx: fiber, fluid intake, sitz bath
46
perianal abscess/ fistula
infection of anal gland, trauma, anal surgery, cancer s/s: swelling, local erythema, swelling fistula: recurrent abscess in same location tx: access; I and D abx alone not enough fistula: surgery
47
pilondial dz
access in the sacrococcynea cleft - pain low back I and D
48
hemorrhoids
veins in rectum BRBRR, painless internal: painless BRBPRB external: pain and swelling tx: external: supporting, analgesics, sits baths opioids thrombosed elliptical incision any grade 4 tx is surgery
49
anal cancer
related to HPV squamous cell ca s/s: bleeding, pain,mass dx: ct/ Mri- look for mets LN needle bx tx: chemo
50
diarrhea
acute 4 weeks inflame- with blood non-inflammaroty- no blood issue
51
acute diarrhea
c.diff
52
chronic diarrhea
osmotic- lactose intolerance- stops with out food secretory diarrhea- gastronoma , malabsortption if still is greasy--. CF, pantreactiis, ZE if blood/ pus- inflame community outbreak - tx: depends on reason midl dx: loperamide, nutrition support opioids- not for infectious diarrhea
53
diarrhea pearls
``` giardia- flagyl shigella: bacterium or cipro campylobacter: erythromycin or copra c. diff;- stop abx if possible, consider flagyl traveler's diarrhea: copra or bactrim ``` no abx on salmonella no ETOh with flagyl foodborn toxigen - no abx lopermide- caution with coli O157: H7 doxy/ bacterium
54
PKU
- rare autosomal condition - unable to metabolic phenylanalina and cover it to tyrosine screen pts at birth dx: s/p age 3> brain damage complicaitons: developed delay movement disorder management: low phenylalanine diet
55
lactose intolerance
osmotic diarrhea bette with no dirty s/s: bloating, flatuence, diarrhea, s/p ingestion management: avoid dairy use OTC lactase enzyme tablets/ drops
56
nutrition dz
A, D, E, K- malabsorption - fatty diarrhea Niacin--flusig thiamine dry beriberi- neuron wet beribi-cardiac folate- megablastic anemia no green tea for preggers