GTR- Osseous Grafts Flashcards
Do you need a blood supply for bone regeneration?
Yes!
How do we get a blood supply for bone regeneration?
Cortical perforation
Biologic Requirements for Bone Regeneration
- Blood supply
- Stabilization
- Osteoblasts
- Confined space
- Space maintenance
- Wound coverage
Bone forms by osteoblast migration from the defect margins, and is a scaffold for bone growth.
Neither inhibits nor induces bone formation.
Osteoconduction
New bone formation through stimulation of osteoprogenitors to differentiate into osteoblasts.
Osteoinduction
When bone cells migrate from the bone margin.
Osteoconduction
When bone is made.
Osteogenesis
The only graft material that’s osteoconductive, osteoinductive, AND osteogenic.
Autograft
All graft materials are what?
OsteoCONDUCTIVE
Advantage of using an alloplast.
Less risk of infectious disease.
Cheaper.
Graft that’s widely used to treat infrabony defects.
Autografts
Why do we prefer to use cortical bone as a bone graft?
1) Has less antigens when it’s freeze-dried.
2) Has more BMPs
A mixture of bone dust and blood
Osseous coagulum
Disadvantage of osseous coagulum
Inadequate amounts for large defects.
Where does intraoral cancellous bone come from?
1) Maxillary tuberosity
2) Edentulous area
3) Healing socket
Extraoral graft site that’s an autograft?
Anterior Iliac Crest
Why is grafting from the hip not recommended?
Morbidity of the donor site.
Risk of transmitting these diseases from an allograft.
1) Hepatitis
2) HIV
3) Prion Disease (Mad Cow Disease)
What’s the best graft material for intraosseous defects?
Demineralized Freeze-dried bone allografts.
Is DFDBA osteoinductive or conductive?
INDUCTIVE!
What is the particle size that’s critical for neovascularization and ingrowth of bone?
100 - 1000 mm
Processing that inactivates HIV.
- Freeze drying
- Alcohol Wash
- Acid demineralization
What type of infection is NOT eliminated by autoclaving or heat sterilization?
Prion disease
Alloplastic materials include what?
Calcium Phosphate and Sulfate
