Green book 1 flashcards
In iodine sufficient areas, is hyper or hypothyroidism from amiodarone therapy more common
Hypothyroidism
What are the types of amiodarone induced thyrotoxicosis
Type 1: abnormal gland w pre existing pathology (e.g. multinodular goiter or latent Graves’) increased synthesis of T3/4
Type 2: a destructive thyroiditis that results in excess release of T3/4. Due to direct toxic effect of amiodarone on thyroid follicular epithelial cells.
Manifestations of amiodarone induced thyrotoxicosis
Atrial arrythmias
Exacerbation of IHD/HF
Unexplained weight loss, restlessness, or low grade fever
How to distinguish between Type 1 and 2 amiodarone induced thyrotoxicosis
Doppler US - type I increased vascularity, II decreased
Type I have goiters
Treatment of type 1 amiodarone induced thyrotoxicosis
- Complex decision making re stopping amiodarone - how essential is amiodarone, long half life (100 days),
- Thionamides
- Radioiodine (but increased uptake)
- Surgery - thyroidectomy
Treatment of type 2 amiodarone induced thyrotoxicosis
Steroids
Nephrotic syndrome + RA - what systemic disease
Amyloidosis
Nephrotic syndrome and myeloma - what systemic disease
Amyloidosis
How to diagnosis amyloidosis
Biopsy - fat pad or rectal or involved site
Light chain amyloidosis - pathophysiology and organs involved
Primary amyloidosis from plasma cell dyscrasia w monoclonal immunoglobulin
Associated with MM or waldenstrom’s or non Hodgkin’s lymphoma
Organs involved: Mucocutaneous - petechia/ecchymosis, raccoon eyes, allopecia, papules/nodules Tongue - macroglossia Heart - ischaemic, arrhythmia, orthostatic hypotension, Other vascular: claudication Renal- proteinuria, nephrotic syndrome GI - haemorrhage/malabsorption Hepatomegaly Neuropathies - autonomic/sensory
Serum amyloid A protein amyloidosis - pathophysiology and manifestations
Secondary amyloidosis to inflammatory/infective chronic conditions
Organs involved:
- Kidney - 90% of patients
- Liver and spleen (howell jolly bodies)
- GI (rare)
- Cardiac - AA deposites (less than AL amyloidosis)
What titre of ANA is more suggestive of autoimmune disorder
> 1:640
What ANA pattern is linked to limited scleroderma
Anti-centromere
What antibodies are found in primary Sjogren’s
Ro/La
What ENAs are SLE specific
dsDNA, anti Sm
What ENA is found in mixed CTD
U1RNP
What ENA is found in diffuse systemic sclerosis
SCL-70
What ENA is found in anti-synthetase syndrome
Jo-1
What ENA is associated with congenital heart block
anti Ro (SSA)
What at the antiphospholipid antibodies
Lupus anticoagulant
Anticardiolipin antibodies
Beta2-glycoprotein-1 antibodies
Most common venous thrombus site in antiphospholipid syndrome
Calf
Most common arterial thromboses site in antiphospholipid syndrome
Cerebral vessels
Diagnostic criteria for antiphospholipid syndrome
+ve antiphospholipid antibody (need repeat measurement 12 weeks apart)
AND
At least 1 clinical feature (venous/arterial thromboses, recurrent foetal loss, thrombocytopenia)
Primary thrombosis prevention in patients who have antiphospholipid antibodies
Not indicated if they have not had a thrombotic event or if they have only had a pregnancy morbidity
Aspirin may have a role in cardiovascular risk reduction
CHADS2 risk criteria score
Prior stroke Age >65 score 1 >75 score 2 HTN DM HF EF <40% Valvular heart disease Female sex Vascular disease
Consensus practice guidelines for warfarin bridging in surgery
No bridging for CHADS2 <4
Can bridge for CHADS2 5/6 or high bleeding risk procedures
How to bridge warfarin if required
stop warfarin 5 days before procedure and bridge w LMWH 3 days before and restart LMWH 24 hours after procedure and up to 10 days while warfarin reintroduced
Aims of rate control in AF
60-80 bpm at rest and 90 to 115 beats per minute during moderate exercise
How long to anticoagulate for before and after cardioversion
3 weeks before and 4 weeks after
What agents can be used in maintenance of sinus after DC cardioversion?
Amiodarone
Sotalol
Flecanide (<60yr and no structural heart disease)
Ends of DMARDs:
- cept
- mab
- ximab
- zumab
- tinib
cept - fusion mab - mAb ximab - chimeric mAb zumab - humanized mAb tinib - tyrosine kinase inhibitor
Secukinumab mechanism of action
IL 17