graves disease - hyperthyroidism

Question 1

x

Answer 1

x

Question 2

Most common cause of thyrotoxicosis is ?

Answer 2

Graves’ disease

Question 3

clinical features of graves disease ?

Answer 3

non tender goitre

pretibial myxoedema-orang peel skin lesions

thyroid acropachy, a triad of:
digital clubbing
soft tissue swelling of the hands and feet
periosteal new bone formation

Question 4

Eye signs of Graves’ disease

Answer 4

proptosis (bulging of the eyes)

excessive eye watering,

double vision,

change in visual acuity and eyelid retraction

conjunctival oedema

optic disc swelling

retro-orbital inflammation

Question 5

What is the most important modifiable risk factor for the development of thyroid eye disease?

Answer 5

SMOKING

Question 6

What may exacerbate eye symptoms in Graves’ disease ?

Answer 6

radioiodine

Question 7

Diagnosis of Graves’ disease

Answer 7

TSH receptor stimulating antibody -

Anti -TPO (thyroid peroxidase
antibody - auto antibody -in 75 percent)

Question 8

Diagnosis of Graves’ disease in thyroid testing

Answer 8

TSH is low
T4 is high

Question 9

Diagnosis of graces disease in thyroid scintigraohy ?

Answer 9

diffuse, homogenous, increased uptake of radioactive iodine

Question 10

x

Answer 10

x

Question 11

x

Answer 11

x

Question 12

x

Answer 12

x

Question 13

Tx of graves orbitopathy ?

Answer 13

topical lubricants may be needed to help prevent corneal inflammation caused by exposure

steroids!

radiotherapy

surgery

Question 14

Treatment of graves disease ?

Answer 14

Carbimazole is the correct answer.

Question 15

what is the side effect of carbimazole ?

Answer 15

agranulocytosis

Question 16

inability to close the eyelids may lead to sore, dry eyes. If severe and untreated patients

Answer 16

can be at risk of exposure keratopathy

Question 17

Carbimazole mechanism of action ?

Answer 17

blocks thyroid peroxidase from coupling and iodinating the tyrosine residues on thyroglobulin → reducing thyroid hormone production