Gram Negative Curved Bacilli and Spirochetes Flashcards

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1
Q

What species of bacterium is motile via flagellum?

A

Campylobacter species

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2
Q

What species of Campylobacter commonly causes self-limited gastroenteritis?

A

C. jejuni

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3
Q

What Campylobacter species is a zoonotic infection and obtained from contaminated food?

A

C. jejuni

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4
Q

What Campylobacter species has been isolated from periodontal pockets as well as oral implants?

A

C. rectus

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5
Q

What species of bacterium produces large amount of urease seen in those that colonize the stomach NOT those that colonize intestines?

A

Helicobacter species

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6
Q

What bacteria colonizes the mucous layer of the stomach?

A

Helicobacter pylori

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7
Q

What bacteria tends to be acquired in youth and persists long term?

A

H. pylori

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8
Q

What bacterium causes chronic gastritis and peptic ulcers?

A

H. pylori

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9
Q

What is associated with H. pylori and stomach carcinoma?

A

CagA

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10
Q

What is the first bacterial oncoprotein?

A

CagA

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11
Q

Strains with Cag PAI are associated with increases in what two things?

A

virulence and inflammation

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12
Q

What bacteria is introduced into cells via Type IV secretion system?

A

H. pylori

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13
Q

Phosphorylated CagA binds to _______ that acts as an oncoprotein.

A

SHP2

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14
Q

What virulence factor degrades gastric mucous?

A

mucinase

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15
Q

What virulence factor causes vacuole formation in epithelial cells and calls up neutrophils?

A

vacuolating cytotoxin

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16
Q

What virulence factor neutralizes gastric acid, calls up monocytes and neutrophils, and stimulate pro-inflammatory cytokines

A

urease

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17
Q

In order to ID H. pylori, you can clinically test for what virulence factor?

A

urease

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18
Q

What bacteria is endemic in areas of poor sanitation and is transmitted through the oral-fecal route?

A

V. cholerae

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19
Q

What disease is caused by V. cholerae?

A

Cholera

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20
Q

What disease ranges from asymptomatic colonization to severe, life threatening diarrhea?

A

Cholera

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21
Q

True or False? Untreated severe cholera can lead to death in a few days.

A

True

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22
Q

True or False? Cholera only requires a small infectious dose.

A

False, it requires a high infectious dose

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23
Q

What virulence factor is a phage encoded A-5B toxin?

A

cholera toxin

24
Q

What virulence factor results in increased adenylate cyclase activity and increased cAMP?

A

cholera toxin

25
Q

What causes overactivation of Cl- channels leading to secretion of water and electrolytes?

A

cholera toxin

26
Q

What causes the third most common STI?

A

T. pallidum

27
Q

What is the causative agent of syphilis?

A

T. pallidum

28
Q

What are single, painless lesions on cutaneous membrane surface?

A

chancre

29
Q

What stage of syphilis is characterized by chancre?

A

Primary

30
Q

What stage of syphilis is characterized by generalized mucocutaneous rash?

A

Secondary

31
Q

What stage of syphilis is characterized by gummas?

A

Tertiary/Late

32
Q

What stage of syphilis is characterized by transmission through placenta or birth canal and can cause Hutchinson’s teeth?

A

congenital

33
Q

In what disease is there limited knowledge of virulence factors due to the lack of in vitro cultures or in vivo models?

A

syphilis

34
Q

What is fibronectin coating?

A

a virulence factor that prevents phagocytosis

35
Q

In what disease is most of the tissue damage caused from host immune system?

A

syphilis

36
Q

Most species of _______ lack LPS but instead have lipoproteins and glycolipids.

A

T. denticola

37
Q

Along with Porphyromonas gingivalis and Tannerella forsythia, _________ comprises the “red complex”.

A

T. denticola

38
Q

______ has strong association to the progression of chronic periodonitis (bone loss).

A

T. denticola

39
Q

What is the only motile member of the red complex?

A

T. denticola

40
Q

What bacterium is associated with polymicrobial biofilm?

A

T. denticola

41
Q

What bacterium is seen deep within the pocket where plaque biofilm meets gingival epithelium?

A

T. denticola

42
Q

What bacterium has leucine rich repeats?

A

T. denticola

43
Q

What increases alveolar bone loss when present with t. forsythia?

A

T. denticola

44
Q

When T. denticola is grown with _______, it binds and works together.

A

P. gingivalis

45
Q

What virulence factor degrades intracellular adhesion proteins and downregulates IL-1beta, Il-6, TNF-alpha, and CCL2?

A

densilin

46
Q

What virulence factor is comprised of a histidine kinase (HK) and response regulator (RR)?

A

two-component regulatory systems

47
Q

In a two-component regulatory system, ______ senses the stimuli from the environment and causes autophosphorylation of the _______.

A

HK (histidine kinase), HK

48
Q

In a two-component regulatory system, _______ transfers a phosphate to the _______ receiver domain activating it.

A

HK (histidine kinase), RR (response regulator)

49
Q

A two-component regulatory system leads to ___________ changes.

A

transcriptional

50
Q

__________ is unique to T. denticola; lacks a typical sensing domain but possesses a unique LytTR domain.

A

AtcRS

51
Q

Where does phase variation occur in B. durgddorferi?

A

in the OspC

52
Q

What causes a zoonotic disease from urine water contamination?

A

L. interrogans

53
Q

What bacteria is common to see in Ironman triathlon competitors?

A

L. interrogans

54
Q

What bacteria causes skin/mucosal surface abrasions, chills, headache, and muscle pain?

A

L. interrogans

55
Q

What bacteria is diagnosed via agglutination test (looking for serum antibodies)?

A

L. interrogans