Gram Negative Curved Bacilli and Spirochetes Flashcards
What species of bacterium is motile via flagellum?
Campylobacter species
What species of Campylobacter commonly causes self-limited gastroenteritis?
C. jejuni
What Campylobacter species is a zoonotic infection and obtained from contaminated food?
C. jejuni
What Campylobacter species has been isolated from periodontal pockets as well as oral implants?
C. rectus
What species of bacterium produces large amount of urease seen in those that colonize the stomach NOT those that colonize intestines?
Helicobacter species
What bacteria colonizes the mucous layer of the stomach?
Helicobacter pylori
What bacteria tends to be acquired in youth and persists long term?
H. pylori
What bacterium causes chronic gastritis and peptic ulcers?
H. pylori
What is associated with H. pylori and stomach carcinoma?
CagA
What is the first bacterial oncoprotein?
CagA
Strains with Cag PAI are associated with increases in what two things?
virulence and inflammation
What bacteria is introduced into cells via Type IV secretion system?
H. pylori
Phosphorylated CagA binds to _______ that acts as an oncoprotein.
SHP2
What virulence factor degrades gastric mucous?
mucinase
What virulence factor causes vacuole formation in epithelial cells and calls up neutrophils?
vacuolating cytotoxin
What virulence factor neutralizes gastric acid, calls up monocytes and neutrophils, and stimulate pro-inflammatory cytokines
urease
In order to ID H. pylori, you can clinically test for what virulence factor?
urease
What bacteria is endemic in areas of poor sanitation and is transmitted through the oral-fecal route?
V. cholerae
What disease is caused by V. cholerae?
Cholera
What disease ranges from asymptomatic colonization to severe, life threatening diarrhea?
Cholera
True or False? Untreated severe cholera can lead to death in a few days.
True
True or False? Cholera only requires a small infectious dose.
False, it requires a high infectious dose