Graded dose And Quantal Dose Response Relationship/ CLINICAL DOSE RESPONSE

Question 1

Means that the intensity or drug effect can increases as the drug dose is increased

Answer 1

Graded dose-response relationship

Question 2

How much drugs

Answer 2

Graded

Question 3

How many drugs

Answer 3

Quantal

Question 4

What is the effect of drugs

Answer 4

Clinical

Question 5

The smallest dose at which death occurs.

Answer 5

Threshold dose or minimal lethal of effective dose

Question 6

The differences in the susceptibility to chemicals among individuals

Answer 6

Biologic Variation

Question 7

Two important factors to consider during the drug test are:

Answer 7

-effective dose(ED)
-lethal dose(LD) or toxic dose(TD)

Question 8

Term used to refer to any unwanted effects other than death.

Answer 8

Lethal dose

Question 9

Can be constructed for responses that are measured on a continuous scale, eg, heart rate.

Answer 9

Graded dose-response-curve

Question 10

Can be constructed for drugs that elicit an all-or-non response, eh, presence or absence of epileptic seizures.

Answer 10

Quantal dose-response curve

Question 11

Examples of specific drugs include:

Answer 11

-atropine( a muscarinic antagonist)
-salbutamol
- phenoxybenzamine(an a-alergic blocking agent)
-cimetidine

Question 12

Is the ration of the dose that results in an undesired effect to that which results in a desired effect.

Answer 12

Therapeutic index

Question 13

Describe how avidly the drug binds to the receptor

Answer 13

Affinity

Question 14

Refers to the concentration or dose of a drug required to produce 50% of the drugs maximal effect

Answer 14

Potency

Question 15

(also reffered to as intrinsic activity) of a drug is the ability of the drug to elicit a response when it binds to the receptor.

Answer 15

Efficacy

Question 16

The concentration of an antagonist that reduces a specified response to 50% of the maximal possible effect.

Answer 16

Median inhibitory concentration

Question 17

Refers to a drug’s ability to preferentially produce a particular effect and is related to the structural specificity of drug binding to receptors.

Answer 17

Selectively