GP

Question 1

When do mothers have their checks after giving birth?

Answer 1

after giving birth and 6-8 weeks

Question 2

What kind of things should you ask in a babycheck

Answer 2

Bladder and bowl function (can be constipated after birth)
Pain (if rectus muscle splits ==> Examing abdomen
Vaginal prolapse (do pelvic floor exercises)

Question 3

How long should a women not drive after c sections?

Answer 3

6 weeks

Question 4

What is locia?

Answer 4

Bleeding after giving birth. at can last around 6 weeks afterwards

Question 5

What Safeguarding issues should you look for at a baby check

Answer 5

FGM (going abroad)
Domestic abuse
Drug/alcohol intake
Discuss contraception as well

Question 6

What mental health checks can you use to look for post natal depression

Answer 6

PHQ-9 and Edinburgh Postnatal depression scale

Question 7

What Examinations would you do at a 8 week baby check?

Answer 7

Blood pressure, weigh, vaginal examination if necesscary, check abdomen

Women with gestational diabetes need a Hba1c

Question 8

What 3 things do you track on a baby 0-1 growth chart

Answer 8

Weight
Length
Head Circumference

Question 9

What is in the 6 in one Vaccination should occur in at 8 weeks?

Answer 9

6 in one

6 in 1 vaccine (DTaP/IPV/Hib/HepB) which protects

against diptheria, tetanus, pertussis (whooping cough), polio, Haemophilus
influenzae type b and hepatitis B

Question 10

What other 3 vacinations, other than the 6 in one, is given at 8 weeks?

Answer 10

the pneumococcal vaccine, rotavirus
vaccine, Men B vaccine.

Question 11

List some ways in which paracetamol can be administered

Answer 11

orally (PO) via tablet, capsule, suspension,
orodispersible tablet or effervescent tablet, per-rectum (pr) via suppository,
intra-venous (iv) via solution for infusion.

Question 12

after giving birth and 6-8 weeks

Answer 12

When do mothers have their checks after giving birth?

Question 13

Depression Medications: How do SSRIs work?

Answer 13

Blocks the reuptake of serotonin back into the cells, so more stays outside, to try and lift the mood. Dose can be increased if necesscary

Question 14

Depression Medications: How do TCAs work?

Answer 14

Tricyclicv Antidepressanets, eg anatripoline, not used often now:

block the reuptake of serotonin and norepinephrine in presynaptic terminals, which leads to increased concentration of these neurotransmitters in the synaptic cleft. The increased concentrations of norepinephrine and serotonin in the synapse likely contribute to its anti-depressive effect

Question 15

Depression Medications: How do SNRIs work?

Answer 15

Selective Norepinephrine reuptake inhibitor, newer eg vendofaxcine,

SNRIs block the reabsorption (or reuptake) of serotonin and norepinephrine back into the nerve cells that released them.

Both of these neurotransmitters are associated with distinct brain structures and functions and impact various processes such as mood and energy in somewhat different ways.

Question 16

Give some psychological symptoms of depression

Answer 16

Continuous low mood or sadness
feeling hopeless and helpless
having low self-esteem
feeling tearful
feeling guilt-ridden
feeling irritable and intolerant of others
having no motivation or interest in things
finding it difficult to make decisions
not getting any enjoyment out of life
feeling anxious or worried
having suicidal thoughts or thoughts of harming yourself

Question 17

Give some physical symptoms of depression

Answer 17

moving or speaking more slowly than usual
changes in appetite or weight (usually decreased, but sometimes increased)
constipation
unexplained aches and pains
lack of energy
low sex drive (loss of libido)
changes to your menstrual cycle
disturbed sleep – for example, finding it difficult to fall asleep at night or waking up very early in the morning

Question 18

Give 2 social symptoms of depression

Answer 18

avoiding contact with friends and taking part in fewer social activities
neglecting your hobbies and intere

Question 19

What can St Johns Wort be used for? What is it also known as?

Answer 19

St John’s wort is a herbal medicine used to treat mental health problems. The botanical name for St John’s wort is Hypericum perforatum, and it is sometimes marketed and sold as ‘Hypericum’. It contains many active substances, including hypericin and hyperforin, which are thought to affect mood.

Today St John’s wort is mainly used as an over-the-counter remedy to treat mild or moderate depression.

Question 20

What are the 4 main continence mechanisms?

Answer 20

internal sphincter
external sphincter
Pelvic floor muscles
Prostate in men

Question 21

What are the 3 types of Lower Urinary Tract symptoms? Give examples of each

Answer 21

Storage - eg frequency, urgency, nocturia, incontinence

Voiding - Poor flow, straining, Hesitancy, Terminal Dribbling

Post Micturition - Sensation of incomplete voiding, Post - micturition dribbling

Question 22

What are some investigations you can do for a patient presenting with LUTs?

Answer 22

Post void bladder scan
U and Es
Bladder diary
Urine dipstick
PR/DRE exam
Flowmetry
Take a History

Question 23

What are some LUTs? Think of Mnemonic

Answer 23

FUNI SHID

Frequency
Urgency
Nocturia
Incontinence

Straining
Hesitancy
Intermittent stream
Dribbling

Question 24

What is a key medication given in rheumatoid arthritis?

Answer 24

Methotrexate

Question 25

What should you give alongside methotrexate?

Answer 25

Folic acid it is contraindicated in pregnancy.

Question 26

What is the mode of action for methotrexate?

Answer 26

Methotrexate is a folate antagonist. Methotrexate inhibits dihydrofolate reductase (DHFR), the enzyme that reduces folic acid to tetrahydrofolic acid This leads in a deficiency in the cellular pools of thymidylate and purines. ======>leads to **a decrease in nucleic acid synthesis.** Therefore, methotrexate **interferes with DNA synthesis, repair, and cellular replication.**

Question 27

Outline some differences between osteoarthritis and rheumatoid arthritis

Answer 27

Rheumatoid - **most common systemic (whole-body) autoimmune disease** Caused by autoimmune, - so inflammation of joints is primary Can damage other organs, not just joints Will often affect multiple joints, symmetrically RA also causes flu-like symptoms, such as fever and malaise (a general unwell feeling). Usually affects MCP and PIP joints in hand, not DIP. Earlier onset Morning stiffness for more than 30 mins Osteoarthritis - **most common arthritis** Caused by wearing down of articular cartilage between bones, any inflammatory is secondary Is limited to just effecting the joints Does not cause systemic, flu like symptoms Typically later onset than RA Pain in 1st Carpo-metacrapal morning stiffness passes in less than 30 minutes usually affects DIP

Question 28

What things should you ask a patient when taking a history for epilepsy?

Answer 28

Whether they've any seizures before Any triggering factors any prodromal features/aura How long it lasted Family history of seizures Allergies Drugs/Alcohol history Character of seizure - Tongue biting, incontinence, loss of consciousness Time taken to recover Drug history Tiredness/stress levels, Whether they drive Occupation

Question 29

What is the management for someone with status epilepticus?

Answer 29

ABCDE approach - secure airway and give oxygen. **IV bolus—to stop seizures: eg lorazepam 4mg** (in hostpial) Give 2nd dose of lorazepam if no response after 10–20min **Or Buccal Midazolam, or rectal diazepam** *(try cannulating a fitting person)* Then Phenytoin if second dose doesn't work. Get ITU/Anaesthetist help!!

Question 30

Treatment of epilepsy - how does Lamotrigine and Carbamazepine work

Answer 30

Lamotrigine and Carbamazepine both inhibit voltage gated pre synaptic Na+ channels - therefore reduces pre synaptic excitability

Question 31

Treatment of epilepsy - how does sodium valproate work?

Answer 31

inhibits an enzyme that leads to an increase in an inhibitor of GABA transaminase ==> Therefore GABA is broken down less aka leads to an increase in GABA/inhibitory neurotransmission

Question 32

What is a contraindication for using Sodium Valporate?

Answer 32

All females of childbearing age (15-45) Sodium Valporate is Teratogenic Can also damage liver, and cause hepatitis Instead use Lamotrigine

Question 33

What are the rules around driving with epilepsy? (Adults with a one off seizure, known epileptics, those driving a HGV vehicle)

Answer 33

**Adults who present with an isolated seizure:** - Should stop driving for 6 months, providing no cause is found on brain imaging and there is no epileptiform activity on EEG Known epileptics Patients must be seizure-free for 12 months before they may qualify for a driving license **If the patient drives a heavy goods vehicle (HGV):** - They must be seizure-free for 5 years before they can start driving

Question 34

name some common side effects of amitriptyline.

Answer 34

Amitriptyline has significant anticholinergic properties. The anticholinergic properties **decrease the effect of the parasympathetic nervous system** and give characteristic symptoms: blurred vision, confusion, dry mouth, urinary retention.

Question 35

What is the MOA of the combined oral contracpetive pill?

Answer 35

Suppress GnRH from anterior pituitary gland, so decreased LH and FSH. LH triggers ovulation