Gout drugs

Question 1

1-Competitive inhibitor of xanthine oxidase
conversion of hypoxanthine and xanthine
to urate.
2-Also used in lymphoma and leukemia
to prevent tumor lysis–associated urate
nephropathy.
3-concentrations of xanthine oxidase active metabolites, azathioprine, and 6-MP.

Answer 1

Allopurinol

Chronic gout drugs

Question 2

Recombinant uricase catalyzing uric acid to
allantoin (a more water-soluble product).

Answer 2

Pegloticase

Chronic gout drugs

Question 3

Inhibits xanthine oxidase.

Answer 3

Febuxostat

Chronic gout drugs

Question 4

Inhibits reabsorption of uric acid in proximal
convoluted tubule (also inhibits secretion of
penicillin). Can precipitate uric acid calculi or lead to sulfa allergy.

Answer 4

Probenecid

Chronic gout drugs

Question 5

Any NSAID. Use salicylates with caution (may decrease uric acid excretion, particularly at low doses).

Answer 5

NSAIDs

Acute gout drugs

Question 6

Oral, intra-articular, or parenteral.

Answer 6

Glucocorticoids

Question 7

Binds and stabilizes tubulin to inhibit
microtubule polymerization, impairing
neutrophil chemotaxis and degranulation.
Acute and prophylactic value. GI,
neuromyopathic adverse effects. Can also
cause myelosuppression, nephrotoxicity.

Answer 7

Colchicine