Cholinomimetic Indirect agonists (anticholinesterases))

Question 1

1st line for Alzheimer disease

Answer 1

Donepezil,
rivastigmine,
galantamine

Don Riva forgot
the gala

Question 2

used to diagnose myasthenia gravis;
replaced by anti-AChR Ab (anti-acetylcholine
receptor antibody) test.

Answer 2

Edrophonium

Question 3

Postoperative and neurogenic ileus and
urinary retention, myasthenia gravis,
reversal of neuromuscular junction blockade
(postoperative).

Answer 3

Neostigmine

Neo CNS = no CNS penetration due to positive
charge.

Question 4

Myasthenia gravis (long acting). Used with
glycopyrrolate, hyoscyamine, or propantheline
to control pyridostigmine adverse effects.

Answer 4

Pyridostigmine

Does not penetrate
CNS

Question 5

Antidote for anticholinergic toxicity physostigmine

Answer 5

Physostigmine

Phreely (freely) crosses blood-brain
barrier as not charged

Question 6

patient with DUMBBELSS.

Answer 6

atropine